The presenilin 2 loop domain interacts with the mu-calpain C-terminal region.

  • Authors:
    • K Shinozaki
    • K Maruyama
    • H Kume
    • T Tomita
    • T C Saido
    • T Iwatsubo
    • K Obata
  • View Affiliations

  • Published online on: May 1, 1998     https://doi.org/10.3892/ijmm.1.5.797
  • Pages: 797-806
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Abstract

Presenilin 2 (PS2) is a gene responsible for the early-onset familial Alzheimer's disease (AD). PS2 mutations are considered to be closely related to the pathogenesis of AD. We screened for proteins that interact with PS2 to understand its pathological and physiological functions. Using the PS2 loop domain as the bait, the yeast two-hybrid system was used for screening, and mu-calpain was identified as a PS2 binding protein. In COS-1 cells, the interaction of PS2 with mu-calpain was confirmed by immunoprecipitation. These results suggested that PS2 and mu-calpain interact with each other, and might regulate each other's functions.

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May 1998
Volume 1 Issue 5

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Shinozaki K, Maruyama K, Kume H, Tomita T, Saido T, Iwatsubo T and Obata K: The presenilin 2 loop domain interacts with the mu-calpain C-terminal region.. Int J Mol Med 1: 797-806, 1998.
APA
Shinozaki, K., Maruyama, K., Kume, H., Tomita, T., Saido, T., Iwatsubo, T., & Obata, K. (1998). The presenilin 2 loop domain interacts with the mu-calpain C-terminal region.. International Journal of Molecular Medicine, 1, 797-806. https://doi.org/10.3892/ijmm.1.5.797
MLA
Shinozaki, K., Maruyama, K., Kume, H., Tomita, T., Saido, T., Iwatsubo, T., Obata, K."The presenilin 2 loop domain interacts with the mu-calpain C-terminal region.". International Journal of Molecular Medicine 1.5 (1998): 797-806.
Chicago
Shinozaki, K., Maruyama, K., Kume, H., Tomita, T., Saido, T., Iwatsubo, T., Obata, K."The presenilin 2 loop domain interacts with the mu-calpain C-terminal region.". International Journal of Molecular Medicine 1, no. 5 (1998): 797-806. https://doi.org/10.3892/ijmm.1.5.797