CD46 (membrane cofactor protein of complement, measles virus receptor): structural and functional divergence among species (review).

  • Authors:
    • T Seya
    • M Nomura
    • Y Murakami
    • N A Begum
    • M Matsumoto
    • S Nagasawa
  • View Affiliations

  • Published online on: May 1, 1998     https://doi.org/10.3892/ijmm.1.5.809
  • Pages: 809-825
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Abstract

Human CD46 was identified as a complement regulator and was later shown to be a measles virus receptor. The ubiquitous distribution profile of CD46 accounted for systemic measles infection and general protection of host tissue/organs from autologous complement. A similar ubiquitous distribution was observed for swine and simian CD46 homologues based upon subsequent cDNA cloning and Northern analysis, reinforcing the roles of CD46. In contrast, recent cDNA cloning and distribution analyses of murine and guinea-pig CD46 revealed the predominant expression of these rodent CD46 homologues in the testis, especially in mature testicular germ cells. These results do not support the established functions of human CD46 but support the hypothesis that CD46 on sperm serves as a fertilization-related adhesion molecule toward eggs. Here, we review the structure, function and distribution of human CD46 and discuss the possible differences between human CD46 and its homologues recently cloned from a variety of non-human primates and other animals.

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May 1998
Volume 1 Issue 5

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Seya T, Nomura M, Murakami Y, Begum N, Matsumoto M and Nagasawa S: CD46 (membrane cofactor protein of complement, measles virus receptor): structural and functional divergence among species (review).. Int J Mol Med 1: 809-825, 1998
APA
Seya, T., Nomura, M., Murakami, Y., Begum, N., Matsumoto, M., & Nagasawa, S. (1998). CD46 (membrane cofactor protein of complement, measles virus receptor): structural and functional divergence among species (review).. International Journal of Molecular Medicine, 1, 809-825. https://doi.org/10.3892/ijmm.1.5.809
MLA
Seya, T., Nomura, M., Murakami, Y., Begum, N., Matsumoto, M., Nagasawa, S."CD46 (membrane cofactor protein of complement, measles virus receptor): structural and functional divergence among species (review).". International Journal of Molecular Medicine 1.5 (1998): 809-825.
Chicago
Seya, T., Nomura, M., Murakami, Y., Begum, N., Matsumoto, M., Nagasawa, S."CD46 (membrane cofactor protein of complement, measles virus receptor): structural and functional divergence among species (review).". International Journal of Molecular Medicine 1, no. 5 (1998): 809-825. https://doi.org/10.3892/ijmm.1.5.809