Expression of HOXD9 in fibroblast-like synoviocytes from rheumatoid arthritis patients

  • Authors:
    • Nguyen Ngoc Chau
    • Takuji Hirose
    • Minako Nakazawa
    • Tetsuji Kobata
    • Hiroshi Nakamura
    • Kusuki Nishioka
    • Toshihiro Nakajima
  • View Affiliations

  • Published online on: July 1, 2002     https://doi.org/10.3892/ijmm.10.1.41
  • Pages: 41-48
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Abstract

The proteins of homeobox (HOX) genes are transcription regulators involved in cell type-specific differentiation and patterning of the body plan in vertebrates. Particularly, the HOXD family is involved in limb formation in mice and chicks. There is also some evidence that the HOXD9 gene, a member of the HOXD family, is involved in the pathology of rheumatoid arthritis (RA). The purpose of the present study was to determine if the HOXD9 protein was expressed in RA synovium and then to characterize the HOXD9-expressing cell. Western blotting and immunohistochemical analysis showed that the HOXD9 protein was expressed in the synovium from patients with RA, but not in those from patients with osteoarthritis or healthy individuals. The HOXD9-positive cells were localized in both the lining and sublining areas of the synovium. Furthermore, fluorescent double-staining showed that the HOXD9 protein was expressed in fibroblast-like synoviocytes (FLS). These findings not only indicate that the HOXD9 gene is exclusively expressed in the RA synovium but also suggest that the HOXD9 gene contributes to the pathology of rheumatoid arthritis through the FLS.

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July 2002
Volume 10 Issue 1

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Chau NN, Hirose T, Nakazawa M, Kobata T, Nakamura H, Nishioka K and Nakajima T: Expression of HOXD9 in fibroblast-like synoviocytes from rheumatoid arthritis patients. Int J Mol Med 10: 41-48, 2002
APA
Chau, N.N., Hirose, T., Nakazawa, M., Kobata, T., Nakamura, H., Nishioka, K., & Nakajima, T. (2002). Expression of HOXD9 in fibroblast-like synoviocytes from rheumatoid arthritis patients. International Journal of Molecular Medicine, 10, 41-48. https://doi.org/10.3892/ijmm.10.1.41
MLA
Chau, N. N., Hirose, T., Nakazawa, M., Kobata, T., Nakamura, H., Nishioka, K., Nakajima, T."Expression of HOXD9 in fibroblast-like synoviocytes from rheumatoid arthritis patients". International Journal of Molecular Medicine 10.1 (2002): 41-48.
Chicago
Chau, N. N., Hirose, T., Nakazawa, M., Kobata, T., Nakamura, H., Nishioka, K., Nakajima, T."Expression of HOXD9 in fibroblast-like synoviocytes from rheumatoid arthritis patients". International Journal of Molecular Medicine 10, no. 1 (2002): 41-48. https://doi.org/10.3892/ijmm.10.1.41