Activation and repression of growth factor receptor gene transcription (Review)

  • Authors:
    • Joseph X. DiMario
  • View Affiliations

  • Published online on: July 1, 2002     https://doi.org/10.3892/ijmm.10.1.65
  • Pages: 65-71
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Abstract

Growth factor receptors mediate cell signaling events that regulate a diverse array of cellular activities including cell proliferation, homeostasis, and differentiation of both normal and cancer cells. Studies of the mechanisms governing transcription of growth factor receptor genes have revealed common structural features of their promoters. These common features include GC rich promoter regions and multiple Sp factor binding sites based upon which most of these promoters are transactivated. Mechanisms of growth factor receptor promoter activation via these common structural features will be reviewed, with particular attention to control of FGFR1 promoter activity in skeletal muscle cells. Of equal importance in cellular function is the repression of growth factor receptor signaling and gene expression. Mechanisms that repress growth factor receptor promoter activity operate via direct repression at transcriptional activator binding sites and via protein-protein interactions that abrogate activator function. Mechanisms of growth factor receptor transcriptional repression will be considered in the context of known tumor suppressors, transcription activator availability, as well as in light of emerging potential Sp1-like transcriptional repressors.

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Journal Cover

July 2002
Volume 10 Issue 1

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
DiMario JX: Activation and repression of growth factor receptor gene transcription (Review). Int J Mol Med 10: 65-71, 2002
APA
DiMario, J.X. (2002). Activation and repression of growth factor receptor gene transcription (Review). International Journal of Molecular Medicine, 10, 65-71. https://doi.org/10.3892/ijmm.10.1.65
MLA
DiMario, J. X."Activation and repression of growth factor receptor gene transcription (Review)". International Journal of Molecular Medicine 10.1 (2002): 65-71.
Chicago
DiMario, J. X."Activation and repression of growth factor receptor gene transcription (Review)". International Journal of Molecular Medicine 10, no. 1 (2002): 65-71. https://doi.org/10.3892/ijmm.10.1.65