The cellular basis of post-burn immunosuppression: Macrophages and mediators (Review)

  • Authors:
    • Martin G. Schwacha
    • Irshad H. Chaudry
  • View Affiliations

  • Published online on: September 1, 2002     https://doi.org/10.3892/ijmm.10.3.239
  • Pages: 239-243
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Major thermal injury induces the activation of an inflammatory cascade that contributes to the development of subsequent immunosuppression, increased susceptibility to sepsis and multiple organ failure. The productive capacity of macrophages for inflammatory mediators, (i.e., nitric oxide, prostaglandins, TNF-α, IL-6 etc.), is profoundly increased post-burn, thereby implicating macrophages in the development of the post-burn immunosuppression. This review will focus on recent findings with regards to the role of macrophages in the development of post-burn immunosuppression with particular emphasis on the role of nitric oxide and prostaglandins.

Related Articles

Journal Cover

September 2002
Volume 10 Issue 3

Print ISSN: 1107-3756
Online ISSN:1791-244X

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Schwacha MG and Chaudry IH: The cellular basis of post-burn immunosuppression: Macrophages and mediators (Review). Int J Mol Med 10: 239-243, 2002.
APA
Schwacha, M.G., & Chaudry, I.H. (2002). The cellular basis of post-burn immunosuppression: Macrophages and mediators (Review). International Journal of Molecular Medicine, 10, 239-243. https://doi.org/10.3892/ijmm.10.3.239
MLA
Schwacha, M. G., Chaudry, I. H."The cellular basis of post-burn immunosuppression: Macrophages and mediators (Review)". International Journal of Molecular Medicine 10.3 (2002): 239-243.
Chicago
Schwacha, M. G., Chaudry, I. H."The cellular basis of post-burn immunosuppression: Macrophages and mediators (Review)". International Journal of Molecular Medicine 10, no. 3 (2002): 239-243. https://doi.org/10.3892/ijmm.10.3.239