The correlation between CpG methylation and protein expression of P16 in oral squamous cell carcinomas

  • Authors:
    • Ming-Jer Huang
    • Kun-Tu Yeh
    • Hung-Chang Shih
    • Yu-Fen Wang
    • Ting-Hsu Lin
    • Jan-Yi Chang
    • Mu-Chin Shih
    • Jan-Gowth Chang
  • View Affiliations

  • Published online on: November 1, 2002     https://doi.org/10.3892/ijmm.10.5.551
  • Pages: 551-554
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Abstract

We examined the P16 expression by immunohistochemical stain and detected the methylation by methylation specific polymerase chain reaction (MSP) in 48 primary oral squamous cell carcinoma (SCC) tissues. The results showed that 20/48 (41.7%) of cancerous tissues had CpG methylation around the promoter region, but 8/48 (17%) of the nearby non-carcerous tissues also had CpG methylation, around the promoter region. The results from immunohistochemical studies showed that reduced and heterogeneous expression of P16 were found in the tissues, which had CpG methylation around the promoter region. In conclusion, the methylation of P16 in oral SCC occurs in pre-cancerous and cancerous stage, which results in decreasing or abolishing the P16 expression, which is heterogeneous in the cancer cells.

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November 2002
Volume 10 Issue 5

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Huang M, Yeh K, Shih H, Wang Y, Lin T, Chang J, Shih M and Chang J: The correlation between CpG methylation and protein expression of P16 in oral squamous cell carcinomas. Int J Mol Med 10: 551-554, 2002
APA
Huang, M., Yeh, K., Shih, H., Wang, Y., Lin, T., Chang, J. ... Chang, J. (2002). The correlation between CpG methylation and protein expression of P16 in oral squamous cell carcinomas. International Journal of Molecular Medicine, 10, 551-554. https://doi.org/10.3892/ijmm.10.5.551
MLA
Huang, M., Yeh, K., Shih, H., Wang, Y., Lin, T., Chang, J., Shih, M., Chang, J."The correlation between CpG methylation and protein expression of P16 in oral squamous cell carcinomas". International Journal of Molecular Medicine 10.5 (2002): 551-554.
Chicago
Huang, M., Yeh, K., Shih, H., Wang, Y., Lin, T., Chang, J., Shih, M., Chang, J."The correlation between CpG methylation and protein expression of P16 in oral squamous cell carcinomas". International Journal of Molecular Medicine 10, no. 5 (2002): 551-554. https://doi.org/10.3892/ijmm.10.5.551