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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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June 2003 Volume 11 Issue 6

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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June 2003 Volume 11 Issue 6

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Article

Effects of thalidomide on the expression of angiogenesis growth factors in human A549 lung adenocarcinoma cells

  • Authors:
    • Xiping Li
    • Xuyi Liu
    • Jie Wang
    • Zengli Wang
    • Wei Jiang
    • Eddie Reed
    • Yi Zhang
    • Yuanlin Liu
    • Q. Quentin Li

  • View Affiliations / Copyright

    Affiliations: Mary Babb Randolph Cancer Center and Department of Microbiology, Immunology and Cell Biology, West Virginia University Robert C. Byrd Health Sciences Center, Morgantown, WV 26506, USA
  • Pages: 785-790
    |
    Published online on: June 1, 2003
       https://doi.org/10.3892/ijmm.11.6.785
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Abstract

Angiogenesis is a critical step for the growth and metastasis of solid tumors, and it is a major therapeutic target for the development of anti-angiogenics for cancer treatment. Thalidomide is reported to be an anti-angiogenic agent, which is currently in phase II clinical trials for the treatment of advanced malignancies. However, the mechanism of thalidomide in angiogenesis is not completely understood. This study was undertaken to investigate the effect of thalidomide on the expression of angiogenesis growth factors in human lung cancer cells. In this report, we show that thalidomide downregulated the mRNA and protein expression of basic fibroblast growth factor (bFGF) in the human lung adenocarcinoma cell line A549, and that the effect of thalidomide was time and concentration-dependent. In contrast, the expression of vascular endothelial growth factor (VEGF) by thalidomide in these cells was in two phases. The mRNA and protein expression of VEGF was increased in the lung cancer cells treated with 0.6-6 μg/ml thalidomide, while higher concentrations of thalidomide decreased VEGF levels significantly in these cells. These data suggest that the anti-angiogenic or antitumor activity of thalidomide may be partly mediated through the regulation of the levels of angiogenesis growth factors.

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Copy and paste a formatted citation
Spandidos Publications style
Li X, Liu X, Wang J, Wang Z, Jiang W, Reed E, Zhang Y, Liu Y and Li QQ: Effects of thalidomide on the expression of angiogenesis growth factors in human A549 lung adenocarcinoma cells. Int J Mol Med 11: 785-790, 2003.
APA
Li, X., Liu, X., Wang, J., Wang, Z., Jiang, W., Reed, E. ... Li, Q.Q. (2003). Effects of thalidomide on the expression of angiogenesis growth factors in human A549 lung adenocarcinoma cells. International Journal of Molecular Medicine, 11, 785-790. https://doi.org/10.3892/ijmm.11.6.785
MLA
Li, X., Liu, X., Wang, J., Wang, Z., Jiang, W., Reed, E., Zhang, Y., Liu, Y., Li, Q. Q."Effects of thalidomide on the expression of angiogenesis growth factors in human A549 lung adenocarcinoma cells". International Journal of Molecular Medicine 11.6 (2003): 785-790.
Chicago
Li, X., Liu, X., Wang, J., Wang, Z., Jiang, W., Reed, E., Zhang, Y., Liu, Y., Li, Q. Q."Effects of thalidomide on the expression of angiogenesis growth factors in human A549 lung adenocarcinoma cells". International Journal of Molecular Medicine 11, no. 6 (2003): 785-790. https://doi.org/10.3892/ijmm.11.6.785
Copy and paste a formatted citation
x
Spandidos Publications style
Li X, Liu X, Wang J, Wang Z, Jiang W, Reed E, Zhang Y, Liu Y and Li QQ: Effects of thalidomide on the expression of angiogenesis growth factors in human A549 lung adenocarcinoma cells. Int J Mol Med 11: 785-790, 2003.
APA
Li, X., Liu, X., Wang, J., Wang, Z., Jiang, W., Reed, E. ... Li, Q.Q. (2003). Effects of thalidomide on the expression of angiogenesis growth factors in human A549 lung adenocarcinoma cells. International Journal of Molecular Medicine, 11, 785-790. https://doi.org/10.3892/ijmm.11.6.785
MLA
Li, X., Liu, X., Wang, J., Wang, Z., Jiang, W., Reed, E., Zhang, Y., Liu, Y., Li, Q. Q."Effects of thalidomide on the expression of angiogenesis growth factors in human A549 lung adenocarcinoma cells". International Journal of Molecular Medicine 11.6 (2003): 785-790.
Chicago
Li, X., Liu, X., Wang, J., Wang, Z., Jiang, W., Reed, E., Zhang, Y., Liu, Y., Li, Q. Q."Effects of thalidomide on the expression of angiogenesis growth factors in human A549 lung adenocarcinoma cells". International Journal of Molecular Medicine 11, no. 6 (2003): 785-790. https://doi.org/10.3892/ijmm.11.6.785
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