Ghrelin: A recently discovered gut-brain peptide (Review)

  • Authors:
    • Marta Alicja Lazarczyk
    • Maciej Lazarczyk
    • Tomasz Grzela
  • View Affiliations

  • Published online on: September 1, 2003     https://doi.org/10.3892/ijmm.12.3.279
  • Pages: 279-287
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

In the 70s, several new, both peptidyl and non-peptidyl, derivatives that stimulate and amplify pulsatile growth hormone (GH) secretion, independently from growth hormone releasing hormone (GHRH), were synthesized. The family of these molecules have been named growth hormone secretagogues (GHSs). The subsequent discovery of the natural receptor for GHSs (GHS-R) suggested existence of a new regulatory system, participating in GH secretion control. Three years later a natural ligand for GHS-R was identified and was designated ‘ghrelin’. Subsequently, it has been found that ghrelin exerts pleiotropic activity. It influences not only GH release but also food intake, function of gastrointestinal tract and cardiovascular system, sleep patterns as well as cancer proliferation. The current knowledge on ghrelin, its structure and function, is reviewed in this article.

Related Articles

Journal Cover

September 2003
Volume 12 Issue 3

Print ISSN: 1107-3756
Online ISSN:1791-244X

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Lazarczyk MA, Lazarczyk M and Grzela T: Ghrelin: A recently discovered gut-brain peptide (Review). Int J Mol Med 12: 279-287, 2003
APA
Lazarczyk, M.A., Lazarczyk, M., & Grzela, T. (2003). Ghrelin: A recently discovered gut-brain peptide (Review). International Journal of Molecular Medicine, 12, 279-287. https://doi.org/10.3892/ijmm.12.3.279
MLA
Lazarczyk, M. A., Lazarczyk, M., Grzela, T."Ghrelin: A recently discovered gut-brain peptide (Review)". International Journal of Molecular Medicine 12.3 (2003): 279-287.
Chicago
Lazarczyk, M. A., Lazarczyk, M., Grzela, T."Ghrelin: A recently discovered gut-brain peptide (Review)". International Journal of Molecular Medicine 12, no. 3 (2003): 279-287. https://doi.org/10.3892/ijmm.12.3.279