Telomerase activation in endometrial epithelial cells by paracrine effectors from stromal cells in primary cultured human endometrium

Oshita,Takafumi; Nagai,Nobutaka; Mukai,Keiji; Shigemasa,Kazushi; Hiura,Masamichi; Ohama,Koso

doi:10.3892/ijmm.13.3.425

March 2004 Volume 13 Issue 3

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March 2004 Volume 13 Issue 3

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Article

Telomerase activation in endometrial epithelial cells by paracrine effectors from stromal cells in primary cultured human endometrium

Authors:
- Takafumi Oshita
- Nobutaka Nagai
- Keiji Mukai
- Kazushi Shigemasa
- Masamichi Hiura
- Koso Ohama
View Affiliations / Copyright

Affiliations: Department of Gynecology and Clinical Research, National Shikoku Cancer Center, Matsuyama 790-0007, Japan. toshita@shikoku-cc.go.jp
Pages: 425-430
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Published online on: March 1, 2004

https://doi.org/10.3892/ijmm.13.3.425
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Abstract

Uterine endometrium displays telomerase activity in a menstrual cycle-dependent manner, despite its somatic origin. This study was performed to elucidate the regulation of telomerase in human endometrium. Telomerase activity and human telomerase reverse transcriptase mRNA expression in proliferative endometrium were significantly stronger than those in secretory endometrium. Their expression was only detected in epithelial cells, although stromal cells also showed proliferation. The growth of epithelial cells decreased day by day in accordance with the decline of telomerase activity. Telomerase activity was significantly stronger in co-cultures of epithelial and stromal cells than in cultures of epithelial cells alone. Moreover, the telomerase activity of co-cultured cells was increased by estradiol or basic fibroblast growth factor, whereas that of epithelial cells cultured alone showed no change. Thus, human endometrium shows reversible telomerase activation during the menstrual cycle, unlike cancer tissues. Also, the telomerase activity of uterine endometrial epithelial cells might be modulated by paracrine effectors released from stromal cells, and not only by the direct action of sex steroids such as estradiol and progesterone.

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Telomerase activation in endometrial epithelial cells by paracrine effectors from stromal cells in primary cultured human endometrium

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Abstract

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