Expression of matrix metalloproteinases and tissue inhibitors of metalloproteinase in uterine endometrial carcinoma and a correlation between expression of matrix metalloproteinase-7 and prognosis

  • Authors:
    • Fumiko Misugi
    • Toshiyuki Sumi
    • Eri Okamoto
    • Hiroyuki Nobeyama
    • Kanae Hattori
    • Hiroyuki Yoshida
    • Yoshinari Matsumoto
    • Tomoyo Yasui
    • Ken-ichi Honda
    • Osamu Ishiko
  • View Affiliations

  • Published online on: October 1, 2005     https://doi.org/10.3892/ijmm.16.4.541
  • Pages: 541-546
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Matrix metalloproteinases (MMPs) are associated with invasion and metastasis of several human malignant tumors, in particular MMP-7, which is mainly produced by the cancer cell itself. We examined the expression of MMP-2, 7 and 9, and tissue inhibitors of metalloproteinase (TIMP)-1 and 2 in uterine endometrial carcinoma, and compared the expression with clinicopathological characteristics in uterine endometrial carcinoma (UEC). A group of 256 patients with UEC received surgery at the Osaka City University Medical School Hospital, and 196 tumor samples were immunohistochemically stained to examine the expression of MMP-2, 7 and 9, and TIMP-1 and 2. Additionally, the invasion ability of cell stain established from UEC was examined using an in vitro invasion assay. The expression of MMP-2, 7 and 9, and TIMP-1 and 2 was observed in the cytoplasm, and the expression of MMP-2 and 7, and TIMP-1 and 2 was observed in stromal cells around the tumor cells. The expression of MMP-7 was significantly stronger in higher-grade than lower-grade tumors (P<0.05). The invasion assay showed that the invasion of cells derived from UECs was significantly inhibited by TIMP-1 and 2. The disease-free interval was significantly shorter when MMP-7 expression was intense. This increased expression of MMP-7 in high grade UECs may be associated with tumor invasion and metastasis, and MMP-7 could serve as a prognostic maker in UEC.

Related Articles

Journal Cover

October 2005
Volume 16 Issue 4

Print ISSN: 1107-3756
Online ISSN:1791-244X

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Misugi F, Sumi T, Okamoto E, Nobeyama H, Hattori K, Yoshida H, Matsumoto Y, Yasui T, Honda K, Ishiko O, Ishiko O, et al: Expression of matrix metalloproteinases and tissue inhibitors of metalloproteinase in uterine endometrial carcinoma and a correlation between expression of matrix metalloproteinase-7 and prognosis. Int J Mol Med 16: 541-546, 2005.
APA
Misugi, F., Sumi, T., Okamoto, E., Nobeyama, H., Hattori, K., Yoshida, H. ... Ishiko, O. (2005). Expression of matrix metalloproteinases and tissue inhibitors of metalloproteinase in uterine endometrial carcinoma and a correlation between expression of matrix metalloproteinase-7 and prognosis. International Journal of Molecular Medicine, 16, 541-546. https://doi.org/10.3892/ijmm.16.4.541
MLA
Misugi, F., Sumi, T., Okamoto, E., Nobeyama, H., Hattori, K., Yoshida, H., Matsumoto, Y., Yasui, T., Honda, K., Ishiko, O."Expression of matrix metalloproteinases and tissue inhibitors of metalloproteinase in uterine endometrial carcinoma and a correlation between expression of matrix metalloproteinase-7 and prognosis". International Journal of Molecular Medicine 16.4 (2005): 541-546.
Chicago
Misugi, F., Sumi, T., Okamoto, E., Nobeyama, H., Hattori, K., Yoshida, H., Matsumoto, Y., Yasui, T., Honda, K., Ishiko, O."Expression of matrix metalloproteinases and tissue inhibitors of metalloproteinase in uterine endometrial carcinoma and a correlation between expression of matrix metalloproteinase-7 and prognosis". International Journal of Molecular Medicine 16, no. 4 (2005): 541-546. https://doi.org/10.3892/ijmm.16.4.541