Lansoprazole, a proton pump inhibitor, reduces the severity of indomethacin-induced rat enteritis

  • Authors:
    • Masaaki Kuroda
    • Norimasa Yoshida
    • Hiroshi Ichikawa
    • Tomohisa Takagi
    • Toshimitsu Okuda
    • Yuji Naito
    • Takeshi Okanoue
    • Toshikazu Yoshikawa
  • View Affiliations

  • Published online on: January 1, 2006     https://doi.org/10.3892/ijmm.17.1.89
  • Pages: 89-93
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Abstract

The spread of capsule endoscopy has led to a focus on small intestinal injury induced by non-steroidal anti-inflammatory drugs (NSAIDs). However, it has been proposed that proton pump inhibitors (PPI), a strong anti-secretary agent, have anti-inflammatory action beyond acid suppression. Therefore, we evaluated the biological effects of lansoprazole, a PPI used in the clinical area, in the setting of experimental rat non-steroidal anti-inflammatory drug-induced enteritis. The animals were given indomethacin subcutaneously and the intestinal mucosa was examined 24 h later. Lansoprazole was given subcutaneously just after following indomethacin injection. Single administration of indomethacin at 10 mg/kg provoked severe hemorrhagic lesions in the small intestine, mostly the jejunum and ileum. The levels of thiobarbituric acid-reactive substances (TBARS), the myeloperoxidase (MPO) activity and the content of cytokine-induced neutrophil chemoattractant-1 (CINC-1) in the intestinal mucosa significantly increased in indomethacin-treated groups compared with the sham-operated groups. The development of intestinal lesions in response to indomethacin was dose-dependently prevented by lansoprazole at a dose of 5 mg/kg together with significant suppression of the increased level of TBARS, MPO activities and CINC-1 in the small bowel. Furthermore, the increased CINC-1 mRNA expression after administration of indomethacin was also inhibited by treatment with lansoprazole. These results suggest that lansoprazole administered exogenously prevented the small intestine against indomethacin-induced damage, the action being dependent on its anti-inflammatory and anti-oxidative responses. This evidence supports the theory that PPI have an expanding role beyond acid suppression.

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January 2006
Volume 17 Issue 1

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Kuroda M, Yoshida N, Ichikawa H, Takagi T, Okuda T, Naito Y, Okanoue T and Yoshikawa T: Lansoprazole, a proton pump inhibitor, reduces the severity of indomethacin-induced rat enteritis. Int J Mol Med 17: 89-93, 2006
APA
Kuroda, M., Yoshida, N., Ichikawa, H., Takagi, T., Okuda, T., Naito, Y. ... Yoshikawa, T. (2006). Lansoprazole, a proton pump inhibitor, reduces the severity of indomethacin-induced rat enteritis. International Journal of Molecular Medicine, 17, 89-93. https://doi.org/10.3892/ijmm.17.1.89
MLA
Kuroda, M., Yoshida, N., Ichikawa, H., Takagi, T., Okuda, T., Naito, Y., Okanoue, T., Yoshikawa, T."Lansoprazole, a proton pump inhibitor, reduces the severity of indomethacin-induced rat enteritis". International Journal of Molecular Medicine 17.1 (2006): 89-93.
Chicago
Kuroda, M., Yoshida, N., Ichikawa, H., Takagi, T., Okuda, T., Naito, Y., Okanoue, T., Yoshikawa, T."Lansoprazole, a proton pump inhibitor, reduces the severity of indomethacin-induced rat enteritis". International Journal of Molecular Medicine 17, no. 1 (2006): 89-93. https://doi.org/10.3892/ijmm.17.1.89