Effects of proadrenomedullin N-terminal 20 peptide on the rat pituitary-adrenocortical axis under basal and stressful conditions

  • Authors:
    • Ludwik K. Malendowicz
    • Carlo Macchi
    • Magdalena Nowak
    • Gastone G. Nussdorfer
    • Mariola Majchrzak
  • View Affiliations

  • Published online on: August 1, 2006     https://doi.org/10.3892/ijmm.18.2.285
  • Pages: 285-287
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Abstract

Proadrenomedullin N-terminal 20 peptide (PAMP) derives, along with adrenomedullin (AM), from prepro-AM. AM has been reported to modulate the activity of the hypothalamic-pituitary-adrenal (HPA) axis, and this study aimed at ascertaining whether PAMP exerts similar effects. PAMP was subcutaneously administered to non-stressed and stressed rats, and the plasma concentrations of ACTH and corticosterone were measured by radioimmune assay. In non-stressed rats, PAMP raised ACTH and corticosterone blood levels at 60 min, and ACTH plasma concentration at 120 min. Ether and cold stresses increased the plasma levels of both ACTH and corticosterone, and PAMP dampened HPA axis response to cold stress, without affecting that to ether stress. The conclusion is drawn that PAMP i) stimulates rat HPA axis, through a mechanism similar to that of ether stress; and ii) interferes with the neural pathways involved in the cold stress-induced activation of HPA axis.

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August 2006
Volume 18 Issue 2

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Malendowicz LK, Macchi C, Nowak M, Nussdorfer GG and Majchrzak M: Effects of proadrenomedullin N-terminal 20 peptide on the rat pituitary-adrenocortical axis under basal and stressful conditions. Int J Mol Med 18: 285-287, 2006.
APA
Malendowicz, L.K., Macchi, C., Nowak, M., Nussdorfer, G.G., & Majchrzak, M. (2006). Effects of proadrenomedullin N-terminal 20 peptide on the rat pituitary-adrenocortical axis under basal and stressful conditions. International Journal of Molecular Medicine, 18, 285-287. https://doi.org/10.3892/ijmm.18.2.285
MLA
Malendowicz, L. K., Macchi, C., Nowak, M., Nussdorfer, G. G., Majchrzak, M."Effects of proadrenomedullin N-terminal 20 peptide on the rat pituitary-adrenocortical axis under basal and stressful conditions". International Journal of Molecular Medicine 18.2 (2006): 285-287.
Chicago
Malendowicz, L. K., Macchi, C., Nowak, M., Nussdorfer, G. G., Majchrzak, M."Effects of proadrenomedullin N-terminal 20 peptide on the rat pituitary-adrenocortical axis under basal and stressful conditions". International Journal of Molecular Medicine 18, no. 2 (2006): 285-287. https://doi.org/10.3892/ijmm.18.2.285