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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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August 2006 Volume 18 Issue 2

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

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Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

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Article

Efficient platelet δ-granule release induced by [Ca2+]i elevation is modulated by GPIIbIIIa

  • Authors:
    • Giuliana Gobbi
    • Ivonne Sponzilli
    • Prisco Mirandola
    • Pier Luigi Tazzari
    • Luigi Caimi
    • Antonio Cacchioli
    • Alessandro Matteucci
    • Gabriella Giuliani Piccari
    • Lucio Cocco
    • Marco Vitale

  • View Affiliations / Copyright

    Affiliations: Department of Anatomy, Pharmacology & Forensic Medicine, Human Anatomy Section, University of Parma, Parma, Italy
  • Pages: 309-313
    |
    Published online on: August 1, 2006
       https://doi.org/10.3892/ijmm.18.2.309
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Abstract

Intracellular Ca2+ elevation generates a cascade of events that leads to platelet activation and degranulation. The GPIIbIIIa-ligand molecular complex plays a central role in several aspects of platelet activation. Taking advantage of the flow cytometric simultaneous analysis of surface GPIIbIIIa expression and intracellular serotonin content, we demonstrate here that the functional inhibition of GPIIbIIIa generates an impairment of δ-granule release even upon maximal intracellular Ca2+ elevation. In healthy subjects, the GPIIbIIIa inhibitor tirofiban impairs platelet δ-granule release. Analogously, Glanzmann thrombasthenia patients show an impairment of δ-granule release that is proportional to their residual expression of platelet GPIIbIIIa. These data show that platelet surface expression of functional GPIIbIIIa is required for a fully efficient secretion of δ-granules and serotonin release. The implications of our findings are discussed in the light of the complex interplay between vescicle release and ligand-receptor triggering during platelet activation.

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Copy and paste a formatted citation
Spandidos Publications style
Gobbi G, Sponzilli I, Mirandola P, Tazzari P , Caimi L, Cacchioli A, Matteucci A, Giuliani Piccari G, Cocco L, Vitale M, Vitale M, et al: Efficient platelet δ-granule release induced by [Ca2+]i elevation is modulated by GPIIbIIIa. Int J Mol Med 18: 309-313, 2006.
APA
Gobbi, G., Sponzilli, I., Mirandola, P., Tazzari, P. ., Caimi, L., Cacchioli, A. ... Vitale, M. (2006). Efficient platelet δ-granule release induced by [Ca2+]i elevation is modulated by GPIIbIIIa. International Journal of Molecular Medicine, 18, 309-313. https://doi.org/10.3892/ijmm.18.2.309
MLA
Gobbi, G., Sponzilli, I., Mirandola, P., Tazzari, P. ., Caimi, L., Cacchioli, A., Matteucci, A., Giuliani Piccari, G., Cocco, L., Vitale, M."Efficient platelet δ-granule release induced by [Ca2+]i elevation is modulated by GPIIbIIIa". International Journal of Molecular Medicine 18.2 (2006): 309-313.
Chicago
Gobbi, G., Sponzilli, I., Mirandola, P., Tazzari, P. ., Caimi, L., Cacchioli, A., Matteucci, A., Giuliani Piccari, G., Cocco, L., Vitale, M."Efficient platelet δ-granule release induced by [Ca2+]i elevation is modulated by GPIIbIIIa". International Journal of Molecular Medicine 18, no. 2 (2006): 309-313. https://doi.org/10.3892/ijmm.18.2.309
Copy and paste a formatted citation
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Spandidos Publications style
Gobbi G, Sponzilli I, Mirandola P, Tazzari P , Caimi L, Cacchioli A, Matteucci A, Giuliani Piccari G, Cocco L, Vitale M, Vitale M, et al: Efficient platelet δ-granule release induced by [Ca2+]i elevation is modulated by GPIIbIIIa. Int J Mol Med 18: 309-313, 2006.
APA
Gobbi, G., Sponzilli, I., Mirandola, P., Tazzari, P. ., Caimi, L., Cacchioli, A. ... Vitale, M. (2006). Efficient platelet δ-granule release induced by [Ca2+]i elevation is modulated by GPIIbIIIa. International Journal of Molecular Medicine, 18, 309-313. https://doi.org/10.3892/ijmm.18.2.309
MLA
Gobbi, G., Sponzilli, I., Mirandola, P., Tazzari, P. ., Caimi, L., Cacchioli, A., Matteucci, A., Giuliani Piccari, G., Cocco, L., Vitale, M."Efficient platelet δ-granule release induced by [Ca2+]i elevation is modulated by GPIIbIIIa". International Journal of Molecular Medicine 18.2 (2006): 309-313.
Chicago
Gobbi, G., Sponzilli, I., Mirandola, P., Tazzari, P. ., Caimi, L., Cacchioli, A., Matteucci, A., Giuliani Piccari, G., Cocco, L., Vitale, M."Efficient platelet δ-granule release induced by [Ca2+]i elevation is modulated by GPIIbIIIa". International Journal of Molecular Medicine 18, no. 2 (2006): 309-313. https://doi.org/10.3892/ijmm.18.2.309
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