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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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September 2006 Volume 18 Issue 3

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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September 2006 Volume 18 Issue 3

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Article

Anti-apoptotic hPEBP4 silencing promotes TRAIL-induced apoptosis of human ovarian cancer cells by activating ERK and JNK pathways

  • Authors:
    • Peng Li
    • Xiaojian Wang
    • Nan Li
    • Huabei Kong
    • Zhenhong Guo
    • Shuxun Liu
    • Xuetao Cao

  • View Affiliations / Copyright

    Affiliations: Department of Obstetrics and Gynecology, Qilu Hospital of Shandong University, Shandong, Jinan 250012, P.R. China
  • Pages: 505-510
    |
    Published online on: September 1, 2006
       https://doi.org/10.3892/ijmm.18.3.505
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Abstract

Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) induces apoptosis in a variety of tumor cell lines but not typically in normal or nontransformed cells, which makes TRAIL a desirable therapeutic agent to fight cancer. Human phosphatidylethanolamine-binding protein 4 (hPEBP4) is a recently identified anti-apoptotic molecule and has been shown to be highly expressed in breast and ovarian cancer cells. We demonstrate that silencing of hPEBP4 in CaoV-3 ovarian cancer cells potentiates TRAIL-induced apoptosis. We found that endogenous hPEBP4 interacts with Raf-1 and MEK1 in TRAIL-treated CaoV-3 cells by co-immunoprecipitation analysis. Simultaneously, silencing of hPEBP4 in CaoV-3 cells enhances TRAIL-induced ERK and JNK activation. Moreover, the inhibitors of MEK1 or JNK can reduce hPEBP4-silence-induced TRAIL sensitivity. Therefore, silencing of hPEBP4 in CaoV-3 ovarian cancer promotes TRAIL-induced apoptosis, and the increased MAPK activation is required for the apoptosis sensitization. All these data indicate that silencing of hPEBP4, an important potential target, may be a promising approach for the treatment of ovarian cancer.

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Copy and paste a formatted citation
Spandidos Publications style
Li P, Wang X, Li N, Kong H, Guo Z, Liu S and Cao X: Anti-apoptotic hPEBP4 silencing promotes TRAIL-induced apoptosis of human ovarian cancer cells by activating ERK and JNK pathways. Int J Mol Med 18: 505-510, 2006.
APA
Li, P., Wang, X., Li, N., Kong, H., Guo, Z., Liu, S., & Cao, X. (2006). Anti-apoptotic hPEBP4 silencing promotes TRAIL-induced apoptosis of human ovarian cancer cells by activating ERK and JNK pathways. International Journal of Molecular Medicine, 18, 505-510. https://doi.org/10.3892/ijmm.18.3.505
MLA
Li, P., Wang, X., Li, N., Kong, H., Guo, Z., Liu, S., Cao, X."Anti-apoptotic hPEBP4 silencing promotes TRAIL-induced apoptosis of human ovarian cancer cells by activating ERK and JNK pathways". International Journal of Molecular Medicine 18.3 (2006): 505-510.
Chicago
Li, P., Wang, X., Li, N., Kong, H., Guo, Z., Liu, S., Cao, X."Anti-apoptotic hPEBP4 silencing promotes TRAIL-induced apoptosis of human ovarian cancer cells by activating ERK and JNK pathways". International Journal of Molecular Medicine 18, no. 3 (2006): 505-510. https://doi.org/10.3892/ijmm.18.3.505
Copy and paste a formatted citation
x
Spandidos Publications style
Li P, Wang X, Li N, Kong H, Guo Z, Liu S and Cao X: Anti-apoptotic hPEBP4 silencing promotes TRAIL-induced apoptosis of human ovarian cancer cells by activating ERK and JNK pathways. Int J Mol Med 18: 505-510, 2006.
APA
Li, P., Wang, X., Li, N., Kong, H., Guo, Z., Liu, S., & Cao, X. (2006). Anti-apoptotic hPEBP4 silencing promotes TRAIL-induced apoptosis of human ovarian cancer cells by activating ERK and JNK pathways. International Journal of Molecular Medicine, 18, 505-510. https://doi.org/10.3892/ijmm.18.3.505
MLA
Li, P., Wang, X., Li, N., Kong, H., Guo, Z., Liu, S., Cao, X."Anti-apoptotic hPEBP4 silencing promotes TRAIL-induced apoptosis of human ovarian cancer cells by activating ERK and JNK pathways". International Journal of Molecular Medicine 18.3 (2006): 505-510.
Chicago
Li, P., Wang, X., Li, N., Kong, H., Guo, Z., Liu, S., Cao, X."Anti-apoptotic hPEBP4 silencing promotes TRAIL-induced apoptosis of human ovarian cancer cells by activating ERK and JNK pathways". International Journal of Molecular Medicine 18, no. 3 (2006): 505-510. https://doi.org/10.3892/ijmm.18.3.505
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