Cisplatin-induced apoptosis in human promyelocytic leukemia cells

  • Authors:
    • Maurizio Previati
    • Irene Lanzoni
    • Elisa Corbacella
    • Sara Magosso
    • Valeria Guaran
    • Alessandro Martini
    • Silvano Capitani
  • View Affiliations

  • Published online on: September 1, 2006     https://doi.org/10.3892/ijmm.18.3.511
  • Pages: 511-516
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Abstract

Cis-diamminedichloroplatinum (II) cisplatin (CDDP) is an organometallic compound frequently used in anti-cancer therapy, in particular ovarian, testicular, and head and neck tumors. We found cisplatin was effective against human promyelocytic leukemia cell line HL-60, inhibiting cell cycle progression and inducing time- and concentration- dependent cell death. Presence of nuclear fragmentation, caspase-3 cleavage and annexin V positivity suggests cell death occurred by apoptosis, although DNA internucleosomal fragmentation was not detected. In addition, analysis of malondialdehyde (MDA) production and protein carbonylation indicated that cisplatin increased lipid peroxidation and oxidation of cell proteins. This occurrence was prevented by antioxidants such as N-acetylcysteine (N-aC) and glutathione (GSH), which, consistently, were also able to prevent CDDP-induced cell death. Collectively, these findings indicate that, besides growth inhibition, an increase of oxygen radicals and lipid degradation can account for a significant part of CDDP-induced apoptosis.

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September 2006
Volume 18 Issue 3

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Previati M, Lanzoni I, Corbacella E, Magosso S, Guaran V, Martini A and Capitani S: Cisplatin-induced apoptosis in human promyelocytic leukemia cells. Int J Mol Med 18: 511-516, 2006
APA
Previati, M., Lanzoni, I., Corbacella, E., Magosso, S., Guaran, V., Martini, A., & Capitani, S. (2006). Cisplatin-induced apoptosis in human promyelocytic leukemia cells. International Journal of Molecular Medicine, 18, 511-516. https://doi.org/10.3892/ijmm.18.3.511
MLA
Previati, M., Lanzoni, I., Corbacella, E., Magosso, S., Guaran, V., Martini, A., Capitani, S."Cisplatin-induced apoptosis in human promyelocytic leukemia cells". International Journal of Molecular Medicine 18.3 (2006): 511-516.
Chicago
Previati, M., Lanzoni, I., Corbacella, E., Magosso, S., Guaran, V., Martini, A., Capitani, S."Cisplatin-induced apoptosis in human promyelocytic leukemia cells". International Journal of Molecular Medicine 18, no. 3 (2006): 511-516. https://doi.org/10.3892/ijmm.18.3.511