Germinated barley foodstuff suppresses dextran sulfate experimental colitis in rats: The role of mast cells

  • Authors:
    • Yoshio Araki
    • Osamu Kanauchi
    • Hiroyuki Sugihara
    • Yoshihide Fujiyama
    • Takanori Hattori
  • View Affiliations

  • Published online on: February 1, 2007     https://doi.org/10.3892/ijmm.19.2.257
  • Pages: 257-262
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Abstract

Recent studies have suggested that dietary fiber exerts a therapeutic effect on inflammatory bowel disease patients. The aim of this study was to evaluate the effects of a dietary fiber, germinated barley foodstuff (GBF), derived from the aleurone and scutellum fraction of germinated barley against dextran sulfate sodium (DSS)-induced experimental colitis in rats. Sprague-Dawley rats were fed a 3% DSS diet containing GBF or α-cellulose for 8 days. The mucosal damage (macroscopic and microscopic inflammation) was then quantified. In addition, we evaluated the alterations in the mucosal mast cells and connective tissues. GBF effectively prevented mucosal damage. In addition, GBF suppressed the infiltration of the mucosal mast cells, and prevented the distraction of both collagen and elastic fibers. These effects may be closely associated with its inhibitory effects on mucosal mast cells, and the destruction of the mucosal connective tissues.

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February 2007
Volume 19 Issue 2

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Araki Y, Kanauchi O, Sugihara H, Fujiyama Y and Hattori T: Germinated barley foodstuff suppresses dextran sulfate experimental colitis in rats: The role of mast cells. Int J Mol Med 19: 257-262, 2007
APA
Araki, Y., Kanauchi, O., Sugihara, H., Fujiyama, Y., & Hattori, T. (2007). Germinated barley foodstuff suppresses dextran sulfate experimental colitis in rats: The role of mast cells. International Journal of Molecular Medicine, 19, 257-262. https://doi.org/10.3892/ijmm.19.2.257
MLA
Araki, Y., Kanauchi, O., Sugihara, H., Fujiyama, Y., Hattori, T."Germinated barley foodstuff suppresses dextran sulfate experimental colitis in rats: The role of mast cells". International Journal of Molecular Medicine 19.2 (2007): 257-262.
Chicago
Araki, Y., Kanauchi, O., Sugihara, H., Fujiyama, Y., Hattori, T."Germinated barley foodstuff suppresses dextran sulfate experimental colitis in rats: The role of mast cells". International Journal of Molecular Medicine 19, no. 2 (2007): 257-262. https://doi.org/10.3892/ijmm.19.2.257