Curcumin attenuates the expression of IL-1β, IL-6, and TNF-α as well as cyclin E in TNF-α-treated HaCaT cells; NF-κB and MAPKs as potential upstream targets

Cho,Jae-We; Lee,Kyu-Suk; Kim,Chang-Wook

doi:10.3892/ijmm.19.3.469

March 2007 Volume 19 Issue 3

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March 2007 Volume 19 Issue 3

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Article

Curcumin attenuates the expression of IL-1β, IL-6, and TNF-α as well as cyclin E in TNF-α-treated HaCaT cells; NF-κB and MAPKs as potential upstream targets

Authors:
- Jae-We Cho
- Kyu-Suk Lee
- Chang-Wook Kim
View Affiliations / Copyright

Affiliations: Department of Dermatology, School of Medicine, Keimyung University, Daegu 700-712, Korea
Pages: 469-474
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Published online on: March 1, 2007

https://doi.org/10.3892/ijmm.19.3.469
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Abstract

TNF-α induces some proinflammatory cytokines including IL-1β, IL-6, IL-8, and itself by activation of NF-κB or MAPKs (p38, JNK, ERK). These cytokines play important roles in various inflammatory skin diseases, such as psoriasis. Recently it was also reported that expression of cyclin E is up-regulated by ERK pathway after TNF-α treatment. However, it was unknown whether curcumin, showing inhibitory effects on NF-κB and MAPKs, attenuates the expression of TNF-α-induced IL-1β, IL-6, IL-8, and TNF-α as well as cyclin E expression in HaCaT cells. In this study, we investigated the inhibitory effect of curcumin on expression of proinflammatory cytokines and cyclin E in TNF-α-treated HaCaT cells. We found that curcumin inhibited the expression of TNF-α-induced IL-1β, IL-6, and TNF-α, but not IL-8, in TNF-α-treated HaCaT cells as well as the TNF-α-induced cyclin E expression. In addition, curcumin inhibited the activation of MAPKs (JNK, p38 MAPK, and ERK) and NF-κB in TNF-α-treated HaCaT cells. Taken together, curcumin exerts anti-inflammatory and growth inhibitory effects in TNF-α-treated HaCaT cells through inhibition of NF-κB and MAPK pathways.

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Curcumin attenuates the expression of IL-1β, IL-6, and TNF-α as well as cyclin E in TNF-α-treated HaCaT cells; NF-κB and MAPKs as potential upstream targets

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Abstract

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