Curcumin attenuates the expression of IL-1β, IL-6, and TNF-α as well as cyclin E in TNF-α-treated HaCaT cells; NF-κB and MAPKs as potential upstream targets

  • Authors:
    • Jae-We Cho
    • Kyu-Suk Lee
    • Chang-Wook Kim
  • View Affiliations

  • Published online on: March 1, 2007     https://doi.org/10.3892/ijmm.19.3.469
  • Pages: 469-474
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Abstract

TNF-α induces some proinflammatory cytokines including IL-1β, IL-6, IL-8, and itself by activation of NF-κB or MAPKs (p38, JNK, ERK). These cytokines play important roles in various inflammatory skin diseases, such as psoriasis. Recently it was also reported that expression of cyclin E is up-regulated by ERK pathway after TNF-α treatment. However, it was unknown whether curcumin, showing inhibitory effects on NF-κB and MAPKs, attenuates the expression of TNF-α-induced IL-1β, IL-6, IL-8, and TNF-α as well as cyclin E expression in HaCaT cells. In this study, we investigated the inhibitory effect of curcumin on expression of proinflammatory cytokines and cyclin E in TNF-α-treated HaCaT cells. We found that curcumin inhibited the expression of TNF-α-induced IL-1β, IL-6, and TNF-α, but not IL-8, in TNF-α-treated HaCaT cells as well as the TNF-α-induced cyclin E expression. In addition, curcumin inhibited the activation of MAPKs (JNK, p38 MAPK, and ERK) and NF-κB in TNF-α-treated HaCaT cells. Taken together, curcumin exerts anti-inflammatory and growth inhibitory effects in TNF-α-treated HaCaT cells through inhibition of NF-κB and MAPK pathways.

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March 2007
Volume 19 Issue 3

Print ISSN: 1107-3756
Online ISSN:1791-244X

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APA
Cho, J., Lee, K., & Kim, C. (2007). Curcumin attenuates the expression of IL-1β, IL-6, and TNF-α as well as cyclin E in TNF-α-treated HaCaT cells; NF-κB and MAPKs as potential upstream targets. International Journal of Molecular Medicine, 19, 469-474. https://doi.org/10.3892/ijmm.19.3.469
MLA
Cho, J., Lee, K., Kim, C."Curcumin attenuates the expression of IL-1β, IL-6, and TNF-α as well as cyclin E in TNF-α-treated HaCaT cells; NF-κB and MAPKs as potential upstream targets". International Journal of Molecular Medicine 19.3 (2007): 469-474.
Chicago
Cho, J., Lee, K., Kim, C."Curcumin attenuates the expression of IL-1β, IL-6, and TNF-α as well as cyclin E in TNF-α-treated HaCaT cells; NF-κB and MAPKs as potential upstream targets". International Journal of Molecular Medicine 19, no. 3 (2007): 469-474. https://doi.org/10.3892/ijmm.19.3.469