Bile acid represses the peroxisome proliferator-activated receptor-γ coactivator-1 promoter activity in a small heterodimer partner-dependent manner

  • Authors:
    • Kazuyuki Yamagata
    • Kenji Yoshimochi
    • Hiroaki Daitoku
    • Keiko Hirota
    • Akiyoshi Fukamizu
  • View Affiliations

  • Published online on: May 1, 2007     https://doi.org/10.3892/ijmm.19.5.751
  • Pages: 751-756
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Abstract

Bile acid homeostasis is tightly controlled by the feedback mechanism in which an atypical orphan nuclear receptor (NR), small heterodimer partner (SHP), inactivates several transcription factors. We previously demonstrated that bile acid represses the expression of gluconeogenic genes, including glucose-6-phosphatase (G6Pase), phosphoenolpyruvate carboxykinase (PEPCK), and fructose-1,6-bisphosphatase (FBP1) in an SHP-dependent manner. Recently, peroxisome proliferator-activated receptor-γ (PPAR-γ) coactivator-1 (PGC-1) gene, a coactivator of NRs important for gluconeogenic gene expression, was also downregulated by bile acid in wild-type mice but not in farnesoid X receptor- or SHP-null mice. However, the molecular mechanism for the effect of bile acid on PGC-1 gene expression remains unknown. In the present study, a series of reporter assays demonstrated that the promoter activity of PGC-1 via a member of the forkhead transcription factors, Foxo1, FOXO3a, and Foxo4 was downregulated by treatment with chenodeoxicholic acid and with transfected SHP. These results revealed that bile acid inhibits the promoter activity of PGC-1 in an SHP-dependent manner.

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May 2007
Volume 19 Issue 5

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Yamagata K, Yoshimochi K, Daitoku H, Hirota K and Fukamizu A: Bile acid represses the peroxisome proliferator-activated receptor-γ coactivator-1 promoter activity in a small heterodimer partner-dependent manner. Int J Mol Med 19: 751-756, 2007.
APA
Yamagata, K., Yoshimochi, K., Daitoku, H., Hirota, K., & Fukamizu, A. (2007). Bile acid represses the peroxisome proliferator-activated receptor-γ coactivator-1 promoter activity in a small heterodimer partner-dependent manner. International Journal of Molecular Medicine, 19, 751-756. https://doi.org/10.3892/ijmm.19.5.751
MLA
Yamagata, K., Yoshimochi, K., Daitoku, H., Hirota, K., Fukamizu, A."Bile acid represses the peroxisome proliferator-activated receptor-γ coactivator-1 promoter activity in a small heterodimer partner-dependent manner". International Journal of Molecular Medicine 19.5 (2007): 751-756.
Chicago
Yamagata, K., Yoshimochi, K., Daitoku, H., Hirota, K., Fukamizu, A."Bile acid represses the peroxisome proliferator-activated receptor-γ coactivator-1 promoter activity in a small heterodimer partner-dependent manner". International Journal of Molecular Medicine 19, no. 5 (2007): 751-756. https://doi.org/10.3892/ijmm.19.5.751