Sodium diethyldithiocarbamate, an AIDS progression inhibitor and a copper-binding compound, has proteasome-inhibitory and apoptosis-inducing activities in cancer cells

  • Authors:
    • Haiyan Pang
    • Di Chen
    • Qiuzhi Cindy Cui
    • Q. Ping Dou
  • View Affiliations

  • Published online on: May 1, 2007     https://doi.org/10.3892/ijmm.19.5.809
  • Pages: 809-816
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Diethyldithiocarbamate (DDTC) is a member of the dithiocarbamate family and a potent copper-chelating agent. DDTC was used in a clinical trial for patients with HIV-1 infection and showed a significant delay in progression to AIDS. In this study, we investigated the effects of DDTC-copper complex in human prostate and breast cancer cells. We found that DDTC was capable of binding copper and forming a new complex that potently inhibited the proteasomal chemotrypsin-like activity, decreased expression of androgen receptor (AR), estrogen receptor (ER) α and ERβ proteins, and induced apoptosis in both prostate and breast cancer cells. Our data support the concept of using accumulated copper in cancer cells and tissues as a novel target for chemotherapy. This study provides a mechanistic interpretation for utilization of copper chelators in cancer treatment.

Related Articles

Journal Cover

May 2007
Volume 19 Issue 5

Print ISSN: 1107-3756
Online ISSN:1791-244X

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Pang H, Chen D, Cui QC and Dou QP: Sodium diethyldithiocarbamate, an AIDS progression inhibitor and a copper-binding compound, has proteasome-inhibitory and apoptosis-inducing activities in cancer cells. Int J Mol Med 19: 809-816, 2007
APA
Pang, H., Chen, D., Cui, Q.C., & Dou, Q.P. (2007). Sodium diethyldithiocarbamate, an AIDS progression inhibitor and a copper-binding compound, has proteasome-inhibitory and apoptosis-inducing activities in cancer cells. International Journal of Molecular Medicine, 19, 809-816. https://doi.org/10.3892/ijmm.19.5.809
MLA
Pang, H., Chen, D., Cui, Q. C., Dou, Q. P."Sodium diethyldithiocarbamate, an AIDS progression inhibitor and a copper-binding compound, has proteasome-inhibitory and apoptosis-inducing activities in cancer cells". International Journal of Molecular Medicine 19.5 (2007): 809-816.
Chicago
Pang, H., Chen, D., Cui, Q. C., Dou, Q. P."Sodium diethyldithiocarbamate, an AIDS progression inhibitor and a copper-binding compound, has proteasome-inhibitory and apoptosis-inducing activities in cancer cells". International Journal of Molecular Medicine 19, no. 5 (2007): 809-816. https://doi.org/10.3892/ijmm.19.5.809