Inhibition of insulin release by alpha- and beta-D-galactose pentaacetate.

  • Authors:
    • W J Malaisse
    • M M Kadiata
  • View Affiliations

  • Published online on: September 1, 1998     https://doi.org/10.3892/ijmm.2.3.331
  • Pages: 331-333
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Abstract

Several monosaccharide polyacetate esters display higher biological efficiency than the corresponding unesterified carbohydrates, this being attributable to their capacity to cross the plasma membrane without requiring the intervention of a specific carrier system and to their subsequent intracellular esterase-catalyzed hydrolysis. Some of these esters, however, also exert a direct effect upon a receptor system apparently displaying analogies with that involved in the identification of bitter compounds by taste buds. For instance, under suitable experimental conditions, esters of non-nutrient monosaccharides, such as L-glucose, D-mannoheptulose or 2-deoxy-D-glucose, unexpectedly stimulate insulin release. The present work reveals that alpha-D-galactose pentaacetate and, to a lesser extent, beta-D-galactose pentaacetate both inhibit leucine-induced insulin release in rat pancreatic islets. This indicates that the postulated receptor system displays anomeric specificity and may participate in a negative modulation of insulin secretion. It is proposed that advantage could be taken of the negative insulinotropic action of D-galactose pentaacetate esters to prevent excessive insulin release in pathological situations.

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Sep 1998
Volume 2 Issue 3

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Malaisse W and Malaisse W: Inhibition of insulin release by alpha- and beta-D-galactose pentaacetate.. Int J Mol Med 2: 331-333, 1998
APA
Malaisse, W., & Malaisse, W. (1998). Inhibition of insulin release by alpha- and beta-D-galactose pentaacetate.. International Journal of Molecular Medicine, 2, 331-333. https://doi.org/10.3892/ijmm.2.3.331
MLA
Malaisse, W., Kadiata, M."Inhibition of insulin release by alpha- and beta-D-galactose pentaacetate.". International Journal of Molecular Medicine 2.3 (1998): 331-333.
Chicago
Malaisse, W., Kadiata, M."Inhibition of insulin release by alpha- and beta-D-galactose pentaacetate.". International Journal of Molecular Medicine 2, no. 3 (1998): 331-333. https://doi.org/10.3892/ijmm.2.3.331