Insulin-like growth factor-1 and insulin-like growth factor receptor in thyroid tissues of patients with Graves' disease.

  • Authors:
    • E Maiorano
    • E Perlino
    • V Triggiani
    • M Nacchiero
    • E Giove
    • A Ciampolillo
  • View Affiliations

  • Published online on: October 1, 1998     https://doi.org/10.3892/ijmm.2.4.483
  • Pages: 483-489
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Abstract

Growth factors are frequently involved in the regulation of mitosis and differentiation of several cell types and insulin-like growth factor-1 (IGF-1) is actively involved in the thyroid stimulating hormone-mediated proliferation of thyrocytes. In view of the pivotal role of IGF-1 in thyrocyte proliferation and of the still unsettled role of this growth factor in the pathogenesis of hyperplastic thyroid lesions, we investigated the expression of IGF-1 and of its corresponding receptor, by means of immunohistochemistry, in the surgical specimens obtained from six patients with Graves' disease. Moreover, IGF-1 mRNA expression was analysed in one such case by means of Northern hybridisation. All samples showed consistent intracytoplasmic immunoreactivity for both IGF-1 and IGF-1 receptor; the vast majority of hyperplastic thyrocytes were strongly decorated by the two antibodies used in this study whereas stromal cells displayed IGF-1 immunoreactivity only. IGF-1 mRNA was markedly overexpressed in Graves' disease in comparison with normal thyroid tissues. The results of this study suggest that IGF-1 and IGF-1 receptor may be actively involved in the pathogenesis of Graves' disease; furthermore, IGF-1 and IGF-1 receptor apparently act by different mechanisms (paracrine vs. autocrine) as suggested by their differential expression in epithelial and stromal cells.

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Oct 1998
Volume 2 Issue 4

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Maiorano E, Perlino E, Triggiani V, Nacchiero M, Giove E and Ciampolillo A: Insulin-like growth factor-1 and insulin-like growth factor receptor in thyroid tissues of patients with Graves' disease.. Int J Mol Med 2: 483-489, 1998
APA
Maiorano, E., Perlino, E., Triggiani, V., Nacchiero, M., Giove, E., & Ciampolillo, A. (1998). Insulin-like growth factor-1 and insulin-like growth factor receptor in thyroid tissues of patients with Graves' disease.. International Journal of Molecular Medicine, 2, 483-489. https://doi.org/10.3892/ijmm.2.4.483
MLA
Maiorano, E., Perlino, E., Triggiani, V., Nacchiero, M., Giove, E., Ciampolillo, A."Insulin-like growth factor-1 and insulin-like growth factor receptor in thyroid tissues of patients with Graves' disease.". International Journal of Molecular Medicine 2.4 (1998): 483-489.
Chicago
Maiorano, E., Perlino, E., Triggiani, V., Nacchiero, M., Giove, E., Ciampolillo, A."Insulin-like growth factor-1 and insulin-like growth factor receptor in thyroid tissues of patients with Graves' disease.". International Journal of Molecular Medicine 2, no. 4 (1998): 483-489. https://doi.org/10.3892/ijmm.2.4.483