Novel effect of estrogen on RANK and c-fms expression in RAW 264.7 cells

  • Authors:
    • Nadia Galal
    • Waleed R. El-Beialy
    • Yoshiaki Deyama
    • Yoshitaka Yoshimura
    • Kuniaki Suzuki
    • Yasunori Totsuka
  • View Affiliations

  • Published online on: July 1, 2007     https://doi.org/10.3892/ijmm.20.1.97
  • Pages: 97-101
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Abstract

Temporomandibular disorder (TMD), a progressive disease entity, and osteoarthrosis preferentially affect females, denoting a possible role of estrogen. Using RAW 264.7 cells, the expression of estrogen receptors (ERs) α and β and the consequent effect of estrogen was investigated. We present the novel detection of ER β expression in RAW 264.7 cells. Furthermore, we innovatively demonstrated the increase in expression of both ER α and β, as well as RANK and c-fms, with estrogen treatment. However, a decrease in expression of c-fms, RANK and ER β, and nearly no change in the expression of ER α were experienced upon further increase in estrogen concentrations. These findings lead us to hypothesize a new mechanism of inflammation in TMD.

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July 2007
Volume 20 Issue 1

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Copy and paste a formatted citation
APA
Galal, N., El-Beialy, W.R., Deyama, Y., Yoshimura, Y., Suzuki, K., & Totsuka, Y. (2007). Novel effect of estrogen on RANK and c-fms expression in RAW 264.7 cells. International Journal of Molecular Medicine, 20, 97-101. https://doi.org/10.3892/ijmm.20.1.97
MLA
Galal, N., El-Beialy, W. R., Deyama, Y., Yoshimura, Y., Suzuki, K., Totsuka, Y."Novel effect of estrogen on RANK and c-fms expression in RAW 264.7 cells". International Journal of Molecular Medicine 20.1 (2007): 97-101.
Chicago
Galal, N., El-Beialy, W. R., Deyama, Y., Yoshimura, Y., Suzuki, K., Totsuka, Y."Novel effect of estrogen on RANK and c-fms expression in RAW 264.7 cells". International Journal of Molecular Medicine 20, no. 1 (2007): 97-101. https://doi.org/10.3892/ijmm.20.1.97