Dandelion T-1 extract up-regulates reproductive hormone receptor expression in mice

  • Authors:
    • Xu Zhi
    • Ken-Ichi Honda
    • Koji Ozaki
    • Takuya Misugi
    • Toshiyuki Sumi
    • Osamu Ishiko
  • View Affiliations

  • Published online on: September 1, 2007     https://doi.org/10.3892/ijmm.20.3.287
  • Pages: 287-292
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Abstract

Reproductive hormones exert their actions via receptors in diverse tissues. In this study, we examined the expression of estrogen receptors (ERα and ERβ), progesterone receptor (PR), and follicle-stimulating hormone receptor (FSHR) in the adipose tissue and reproductive organs of mice following oral treatment with Dandelion T-1 extract (DT-1E) for 6 weeks. Quantitative assays by real-time reverse transcription polymerase chain reaction showed enhanced expression of ERα and ERβ mRNA in the adipose tissue of mice fed a diet containing DT-1E compared with the control group fed a plain diet. Furthermore, following gonadotropin injection, higher mRNA expression of ERα, ERβ and PR in the uterus and FSHR in the ovary was found in the DT-1E group compared with the control group. An immunohistochemical study also showed increased levels of the above-mentioned receptors in the DT-1E group. The present study shows that oral intake of DT-1E up-regulates ERα, ERβ, PR and FSHR expression in mice, suggesting the potential application of DT-1E for the clinical treatment of reproductive hormone-related disturbances.

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September 2007
Volume 20 Issue 3

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Zhi X, Honda K, Ozaki K, Misugi T, Sumi T and Ishiko O: Dandelion T-1 extract up-regulates reproductive hormone receptor expression in mice. Int J Mol Med 20: 287-292, 2007
APA
Zhi, X., Honda, K., Ozaki, K., Misugi, T., Sumi, T., & Ishiko, O. (2007). Dandelion T-1 extract up-regulates reproductive hormone receptor expression in mice. International Journal of Molecular Medicine, 20, 287-292. https://doi.org/10.3892/ijmm.20.3.287
MLA
Zhi, X., Honda, K., Ozaki, K., Misugi, T., Sumi, T., Ishiko, O."Dandelion T-1 extract up-regulates reproductive hormone receptor expression in mice". International Journal of Molecular Medicine 20.3 (2007): 287-292.
Chicago
Zhi, X., Honda, K., Ozaki, K., Misugi, T., Sumi, T., Ishiko, O."Dandelion T-1 extract up-regulates reproductive hormone receptor expression in mice". International Journal of Molecular Medicine 20, no. 3 (2007): 287-292. https://doi.org/10.3892/ijmm.20.3.287