Quantitative expression of the homeobox and integrin genes in human gastric carcinoma

  • Authors:
    • Duccio Rossi Degl'Innocenti
    • Francesca Castiglione
    • Anna Maria Buccoliero
    • Paolo Bechi
    • Gian Luigi Taddei
    • Giancarlo Freschi
    • Antonio Taddei
  • View Affiliations

  • Published online on: October 1, 2007     https://doi.org/10.3892/ijmm.20.4.621
  • Pages: 621-629
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Abstract

The homeobox (HOX) genes are a large family of regulator genes involved in the control of developmental processes and cell differentiation. The HOX genes encode transcription factors, and an increasing number of studies have shown that these genes may be implicated in the growth and the progression of many types of tumours. The present study investigated the expression of the HOX and integrin genes and their relationships in gastric carcinoma. We analyzed the RNA expression of 13 HOX genes from HOXA, C and D clusters and αV, α5 and α8 integrin genes in 24 gastric cancer samples by quantitative real-time PCR. The results showed that the HOXA2 gene and the α8 integrin gene had a lower expression in tumour samples than in normal gastric mucosas. The comparison between the HOX and integrin genes showed that HOXA2 and αV integrin expression presented the same trend in 83% of the samples. Moreover, in cancer samples that expressed the HOXD11 gene, the expression of αV integrin was lower with respect to normal mucosas. The different roles of HOX and integrin genes in gastric carcinoma remain to be fully elucidated. These findings suggest that the HOX genes may play a critical role in the genesis, maintenance and diffusion of gastric carcinoma.

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October 2007
Volume 20 Issue 4

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Rossi Degl'Innocenti D, Castiglione F, Buccoliero AM, Bechi P, Taddei GL, Freschi G and Taddei A: Quantitative expression of the homeobox and integrin genes in human gastric carcinoma. Int J Mol Med 20: 621-629, 2007
APA
Rossi Degl'Innocenti, D., Castiglione, F., Buccoliero, A.M., Bechi, P., Taddei, G.L., Freschi, G., & Taddei, A. (2007). Quantitative expression of the homeobox and integrin genes in human gastric carcinoma. International Journal of Molecular Medicine, 20, 621-629. https://doi.org/10.3892/ijmm.20.4.621
MLA
Rossi Degl'Innocenti, D., Castiglione, F., Buccoliero, A. M., Bechi, P., Taddei, G. L., Freschi, G., Taddei, A."Quantitative expression of the homeobox and integrin genes in human gastric carcinoma". International Journal of Molecular Medicine 20.4 (2007): 621-629.
Chicago
Rossi Degl'Innocenti, D., Castiglione, F., Buccoliero, A. M., Bechi, P., Taddei, G. L., Freschi, G., Taddei, A."Quantitative expression of the homeobox and integrin genes in human gastric carcinoma". International Journal of Molecular Medicine 20, no. 4 (2007): 621-629. https://doi.org/10.3892/ijmm.20.4.621