Crosstalk between high-molecular-weight adiponectin and T-cadherin during liver fibrosis development in rats

  • Authors:
    • Kiyoshi Asada
    • Hitoshi Yoshiji
    • Ryuichi Noguchi
    • Yasuhide Ikenaka
    • Mitsuteru Kitade
    • Kosuke Kaji
    • Junichi Yoshii
    • Koji Yanase
    • Tadashi Namisaki
    • Masaharu Yamazaki
    • Tatsuhiro Tsujimoto
    • Takemi Akahane
    • Masahito Uemura
    • Hiroshi Fukui
  • View Affiliations

  • Published online on: November 1, 2007     https://doi.org/10.3892/ijmm.20.5.725
  • Pages: 725-729
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Abstract

Adiponectin, a circulating adipocyte-derived secretory protein, reportedly plays an important role in liver fibrosis development, although the biological role of adiponectin in liver fibrogenesis is still controversial. Adiponectin is present in the serum as three oligometric complexes; namely, high-, middle-, and low-molecular weight (HMW, MMW, and LMW, respectively). Adiponectin exerts different biological activities in an oligomerization-dependent manner. The aim of our current study was to examine the alteration of each isoform of adiponectin and its receptors (AdipoR1, AdipoR2, and T-cadherin) during the choline-deficient L-amino acid-defined (CDAA) diet-induced rat liver fibrosis development. We also elucidated the methylation status of all receptors. The serum level of total adiponectin significantly increased during the liver fibrosis development. Among the three isoforms, only HMW adiponectin was significantly up-regulated whereas MMW and LMW were not. The expression of T-cadherin, which exclusively binds with HMW adiponectin, was significantly augmented as well. The AdipoR2 expression was markedly decreased and showed no marked difference from that of AdipoR1. No obvious methylation change was observed in all three receptors, suggesting that another mechanism is involved in the alteration of receptor gene expression. Collectively, since the specific ligand and receptor were augmented together, crosstalk between HMW adiponectin and T-cadherin may play an important role during liver fibrosis development in rats.

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november 2007
Volume 20 Issue 5

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Asada K, Yoshiji H, Noguchi R, Ikenaka Y, Kitade M, Kaji K, Yoshii J, Yanase K, Namisaki T, Yamazaki M, Yamazaki M, et al: Crosstalk between high-molecular-weight adiponectin and T-cadherin during liver fibrosis development in rats. Int J Mol Med 20: 725-729, 2007
APA
Asada, K., Yoshiji, H., Noguchi, R., Ikenaka, Y., Kitade, M., Kaji, K. ... Fukui, H. (2007). Crosstalk between high-molecular-weight adiponectin and T-cadherin during liver fibrosis development in rats. International Journal of Molecular Medicine, 20, 725-729. https://doi.org/10.3892/ijmm.20.5.725
MLA
Asada, K., Yoshiji, H., Noguchi, R., Ikenaka, Y., Kitade, M., Kaji, K., Yoshii, J., Yanase, K., Namisaki, T., Yamazaki, M., Tsujimoto, T., Akahane, T., Uemura, M., Fukui, H."Crosstalk between high-molecular-weight adiponectin and T-cadherin during liver fibrosis development in rats". International Journal of Molecular Medicine 20.5 (2007): 725-729.
Chicago
Asada, K., Yoshiji, H., Noguchi, R., Ikenaka, Y., Kitade, M., Kaji, K., Yoshii, J., Yanase, K., Namisaki, T., Yamazaki, M., Tsujimoto, T., Akahane, T., Uemura, M., Fukui, H."Crosstalk between high-molecular-weight adiponectin and T-cadherin during liver fibrosis development in rats". International Journal of Molecular Medicine 20, no. 5 (2007): 725-729. https://doi.org/10.3892/ijmm.20.5.725