New trends in non-invasive prenatal diagnosis: Applications of dielectrophoresis-based Lab-on-a-chip platforms to the identification and manipulation of rare cells (Review)

  • Authors:
    • Monica Borgatti
    • Nicoletta Bianchi
    • Irene Mancini
    • Giordana Feriotto
    • Roberto Gambari
  • View Affiliations

  • Published online on: January 1, 2008     https://doi.org/10.3892/ijmm.21.1.3
  • Pages: 3-12
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Abstract

The isolation of rare cells, such as fetal nucleated red blood cells and trophoblasts, from maternal blood for non-invasive prenatal diagnosis is a new field of research exhibiting several difficulties since this strategy requires unresolved basic technological protocols for a successful outcome. However, several achievements in the field of Laboratory-on-a-chip (Lab-on-a-chip) technology have provided clear advancements in projects aimed at the isolation of rare cells from biological fluids. Among the most interesting approaches are those based on dielectrophoresis (DEP). DEP-based Lab-on-a-chip platforms have been demonstrated to be suitable for several applications in biotechnology and biomedicine. DEP-based arrays are able to manipulate single cells, which can be identified and moved throughout the DEP chip to recovery places. DEP buffers are compatible with molecular interactions between monoclonal antibodies and target cells, allowing integration of these devices with magnetic cell sorting (MACS). DEP treatment does not alter the viability of manipulated cells.

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January 2008
Volume 21 Issue 1

Print ISSN: 1107-3756
Online ISSN:1791-244X

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APA
Borgatti, M., Bianchi, N., Mancini, I., Feriotto, G., & Gambari, R. (2008). New trends in non-invasive prenatal diagnosis: Applications of dielectrophoresis-based Lab-on-a-chip platforms to the identification and manipulation of rare cells (Review). International Journal of Molecular Medicine, 21, 3-12. https://doi.org/10.3892/ijmm.21.1.3
MLA
Borgatti, M., Bianchi, N., Mancini, I., Feriotto, G., Gambari, R."New trends in non-invasive prenatal diagnosis: Applications of dielectrophoresis-based Lab-on-a-chip platforms to the identification and manipulation of rare cells (Review)". International Journal of Molecular Medicine 21.1 (2008): 3-12.
Chicago
Borgatti, M., Bianchi, N., Mancini, I., Feriotto, G., Gambari, R."New trends in non-invasive prenatal diagnosis: Applications of dielectrophoresis-based Lab-on-a-chip platforms to the identification and manipulation of rare cells (Review)". International Journal of Molecular Medicine 21, no. 1 (2008): 3-12. https://doi.org/10.3892/ijmm.21.1.3