The efficacy of apolipoprotein E deficiency in cerebral aneurysm formation

  • Authors:
    • Tomohiro Aoki
    • Takuya Moriwaki
    • Yasushi Takagi
    • Hiroharu Kataoka
    • Jiho Yang
    • Kazuhiko Nozaki
    • Nobuo Hashimoto
  • View Affiliations

  • Published online on: April 1, 2008     https://doi.org/10.3892/ijmm.21.4.453
  • Pages: 453-459
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Abstract

Subarachnoid hemorrhage due to the rupture of a cerebral aneurysm is a life-threatening disease. Despite this, the detailed mechanisms underlying the initiation and progression of cerebral aneurysm are unclear. The relation of hypercholesterolemia and apolipoprotein E (ApoE) to cerebral aneurysm formation, has been unclear until now. We used, in the present study, a previously established cerebral aneurysm model of rats and mice whose histological features were closely similar to human cerebral aneurysms. ApoE protein was expressed mainly in the endothelial cells of arterial walls both in control arteries and cerebral aneurysms. The expression of ApoE was reduced during aneurysm formation in the immunohistochemistry. The mRNA expression of ApoE in arterial walls was not different between the controls and cerebral aneurysms. Owing to the deficiency of ApoE, mice presented marked hypercholesterolemia, but there was no difference in cerebral aneurysm formation. In the present study, we clarified that ApoE was not responsible for cerebral aneurysm formation.

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April 2008
Volume 21 Issue 4

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Aoki T, Moriwaki T, Takagi Y, Kataoka H, Yang J, Nozaki K and Hashimoto N: The efficacy of apolipoprotein E deficiency in cerebral aneurysm formation. Int J Mol Med 21: 453-459, 2008
APA
Aoki, T., Moriwaki, T., Takagi, Y., Kataoka, H., Yang, J., Nozaki, K., & Hashimoto, N. (2008). The efficacy of apolipoprotein E deficiency in cerebral aneurysm formation. International Journal of Molecular Medicine, 21, 453-459. https://doi.org/10.3892/ijmm.21.4.453
MLA
Aoki, T., Moriwaki, T., Takagi, Y., Kataoka, H., Yang, J., Nozaki, K., Hashimoto, N."The efficacy of apolipoprotein E deficiency in cerebral aneurysm formation". International Journal of Molecular Medicine 21.4 (2008): 453-459.
Chicago
Aoki, T., Moriwaki, T., Takagi, Y., Kataoka, H., Yang, J., Nozaki, K., Hashimoto, N."The efficacy of apolipoprotein E deficiency in cerebral aneurysm formation". International Journal of Molecular Medicine 21, no. 4 (2008): 453-459. https://doi.org/10.3892/ijmm.21.4.453