Bifidobacterium infantis suppresses proinflammatory interleukin-17 production in murine splenocytes and dextran sodium sulfate-induced intestinal inflammation

  • Authors:
    • Soichi Tanabe
    • Yuki Kinuta
    • Yasuo Saito
  • View Affiliations

  • Published online on: August 1, 2008     https://doi.org/10.3892/ijmm_00000006
  • Pages: 181-185
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Abstract

Interleukin (IL)-17 acts as a potent inflammatory cytokine, and IL-17-producing cells (Th17 cells) have received much attention. However, the involvement of commensal and/or probiotic bacteria in IL-17 production has not been evaluated. In this study, we examined the suppressive effects of five bacteria species on IL-17 production in vitro and ex vivo. Among the five species studied, Bifidobacterium infantis inhibited IL-17 production but enhanced IL-27 production most potently in TGF-β plus IL-6-stimulated murine splenocytes. B. infantis also inhibited IL-17 and eotaxin production from a dextran sodium sulfate-treated colon organ culture. The induction of IL-10 by B. infantis was observed both in the splenocytes and in the colon culture and was assumed, to a certain extent, to be important for suppressing IL-17 production. These findings suggest a novel immunomodulatory function of commensal bifidobacteria and further imply that these bacteria may be useful in the treatment of Th17-mediated diseases.

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August 2008
Volume 22 Issue 2

Print ISSN: 1107-3756
Online ISSN:1791-244X

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APA
Tanabe, S., Kinuta, Y., & Saito, Y. (2008). Bifidobacterium infantis suppresses proinflammatory interleukin-17 production in murine splenocytes and dextran sodium sulfate-induced intestinal inflammation. International Journal of Molecular Medicine, 22, 181-185. https://doi.org/10.3892/ijmm_00000006
MLA
Tanabe, S., Kinuta, Y., Saito, Y."Bifidobacterium infantis suppresses proinflammatory interleukin-17 production in murine splenocytes and dextran sodium sulfate-induced intestinal inflammation". International Journal of Molecular Medicine 22.2 (2008): 181-185.
Chicago
Tanabe, S., Kinuta, Y., Saito, Y."Bifidobacterium infantis suppresses proinflammatory interleukin-17 production in murine splenocytes and dextran sodium sulfate-induced intestinal inflammation". International Journal of Molecular Medicine 22, no. 2 (2008): 181-185. https://doi.org/10.3892/ijmm_00000006