Hemostatic safety of the bolus intravenous injection of a novel medium-chain triglyceride:fish oil emulsion

  • Authors:
    • Olivier Pradier
    • Laurence Portois
    • Willy J. Malaisse
    • Yvon A. Carpentier
  • View Affiliations

  • Published online on: September 1, 2008     https://doi.org/10.3892/ijmm_00000023
  • Pages: 301-307
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Abstract

The bolus intravenous injection of a novel 8:2 medium-chain triglyceride:fish oil emulsion was recently found to increase within 60 min and for the subsequent 24-48 h the long-chain polyunsaturated ω3 fatty acid content of both leucocyte and platelet phospholipids in 12 normal subjects. The aim of the present report is to document the hemostatic safety of such a procedure in the same 12 subjects. No adverse effect was found when comparing the results obtained after administration of either the fish oil-containing emulsion or a control 5:5 medium-chain triglyceride:soybean triglyceride emulsion, whether in terms of the occlusion time in either an ADP or epinephrine test or in terms of the [CD]42b, [CD]62p, fibrinogen and PAC-1 response to ADP, collagen or thrombin receptor analog peptide 6 in platelets examined by fluorescence activated cell sorting. In conclusion, this novel procedure for the rapid enrichment of cell phospholipid in long-chain polyunsaturated ω3 fatty acids presents the required safety in a hemostatic perspective.

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September 2008
Volume 22 Issue 3

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Pradier O, Portois L, Malaisse WJ and Carpentier YA: Hemostatic safety of the bolus intravenous injection of a novel medium-chain triglyceride:fish oil emulsion. Int J Mol Med 22: 301-307, 2008
APA
Pradier, O., Portois, L., Malaisse, W.J., & Carpentier, Y.A. (2008). Hemostatic safety of the bolus intravenous injection of a novel medium-chain triglyceride:fish oil emulsion. International Journal of Molecular Medicine, 22, 301-307. https://doi.org/10.3892/ijmm_00000023
MLA
Pradier, O., Portois, L., Malaisse, W. J., Carpentier, Y. A."Hemostatic safety of the bolus intravenous injection of a novel medium-chain triglyceride:fish oil emulsion". International Journal of Molecular Medicine 22.3 (2008): 301-307.
Chicago
Pradier, O., Portois, L., Malaisse, W. J., Carpentier, Y. A."Hemostatic safety of the bolus intravenous injection of a novel medium-chain triglyceride:fish oil emulsion". International Journal of Molecular Medicine 22, no. 3 (2008): 301-307. https://doi.org/10.3892/ijmm_00000023