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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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September 2008 Volume 22 Issue 3

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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September 2008 Volume 22 Issue 3

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Article

Glucosamine, a naturally occurring amino monosaccharide, suppresses dextran sulfate sodium-induced colitis in rats

  • Authors:
    • Shin Yomogida
    • Yuko Kojima
    • Yuko Tsutsumi-Ishii
    • Jian Hua
    • Koji Sakamoto
    • Isao Nagaoka

  • View Affiliations / Copyright

    Affiliations: Department of Host Defense and Biochemical Research, Biomedical Research Center, Juntendo University, School of Medicine, Tokyo, 113-8421, Japan
  • Pages: 317-323
    |
    Published online on: September 1, 2008
       https://doi.org/10.3892/ijmm_00000025
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Abstract

Glucosamine, a naturally occurring amino monosaccharide, is widely used to treat osteoarthritis in humans. Furthermore, glucosamine exhibits an anti-inflammatory action by inhibiting the activation of neutrophils, chondrocytes and synoviocytes. Recently, we revealed that glucosamine suppresses cytokine-induced activation of intestinal epithelial cells in vitro. In the present study therefore, we investigated whether glucosamine exhibits the anti-inflammatory effect in vivo, using dextran sulfate sodium (DSS)-induced colitis in rats, a model of inflammatory bowel diseases (IBD). The results indicated that glucosamine improved the clinical symptoms (evaluated by disease activity index), and suppressed colonic inflammation (evaluated by colon length and weight/length ratio) and tissue injury (evaluated by histological damage score) in DSS-induced colitis. Furthermore, glucosamine inhibited the activation of intestinal epithelial cells, as evidenced by the suppressed phosphorylation of NF-κB in the intestinal mucosa of DSS-induced colitis. Collectively, these observations suggest that glucosamine is likely to suppress the activation of intestinal epithelial cells in vivo, thereby possibly exhibiting anti-inflammatory action in a DSS-induced rat colitis model. Thus, glucosamine could prove to be a useful agent for IBD.

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Copy and paste a formatted citation
Spandidos Publications style
Yomogida S, Kojima Y, Tsutsumi-Ishii Y, Hua J, Sakamoto K and Nagaoka I: Glucosamine, a naturally occurring amino monosaccharide, suppresses dextran sulfate sodium-induced colitis in rats. Int J Mol Med 22: 317-323, 2008.
APA
Yomogida, S., Kojima, Y., Tsutsumi-Ishii, Y., Hua, J., Sakamoto, K., & Nagaoka, I. (2008). Glucosamine, a naturally occurring amino monosaccharide, suppresses dextran sulfate sodium-induced colitis in rats. International Journal of Molecular Medicine, 22, 317-323. https://doi.org/10.3892/ijmm_00000025
MLA
Yomogida, S., Kojima, Y., Tsutsumi-Ishii, Y., Hua, J., Sakamoto, K., Nagaoka, I."Glucosamine, a naturally occurring amino monosaccharide, suppresses dextran sulfate sodium-induced colitis in rats". International Journal of Molecular Medicine 22.3 (2008): 317-323.
Chicago
Yomogida, S., Kojima, Y., Tsutsumi-Ishii, Y., Hua, J., Sakamoto, K., Nagaoka, I."Glucosamine, a naturally occurring amino monosaccharide, suppresses dextran sulfate sodium-induced colitis in rats". International Journal of Molecular Medicine 22, no. 3 (2008): 317-323. https://doi.org/10.3892/ijmm_00000025
Copy and paste a formatted citation
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Spandidos Publications style
Yomogida S, Kojima Y, Tsutsumi-Ishii Y, Hua J, Sakamoto K and Nagaoka I: Glucosamine, a naturally occurring amino monosaccharide, suppresses dextran sulfate sodium-induced colitis in rats. Int J Mol Med 22: 317-323, 2008.
APA
Yomogida, S., Kojima, Y., Tsutsumi-Ishii, Y., Hua, J., Sakamoto, K., & Nagaoka, I. (2008). Glucosamine, a naturally occurring amino monosaccharide, suppresses dextran sulfate sodium-induced colitis in rats. International Journal of Molecular Medicine, 22, 317-323. https://doi.org/10.3892/ijmm_00000025
MLA
Yomogida, S., Kojima, Y., Tsutsumi-Ishii, Y., Hua, J., Sakamoto, K., Nagaoka, I."Glucosamine, a naturally occurring amino monosaccharide, suppresses dextran sulfate sodium-induced colitis in rats". International Journal of Molecular Medicine 22.3 (2008): 317-323.
Chicago
Yomogida, S., Kojima, Y., Tsutsumi-Ishii, Y., Hua, J., Sakamoto, K., Nagaoka, I."Glucosamine, a naturally occurring amino monosaccharide, suppresses dextran sulfate sodium-induced colitis in rats". International Journal of Molecular Medicine 22, no. 3 (2008): 317-323. https://doi.org/10.3892/ijmm_00000025
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