Glucosamine, a naturally occurring amino monosaccharide, suppresses dextran sulfate sodium-induced colitis in rats

  • Authors:
    • Shin Yomogida
    • Yuko Kojima
    • Yuko Tsutsumi-Ishii
    • Jian Hua
    • Koji Sakamoto
    • Isao Nagaoka
  • View Affiliations

  • Published online on: September 1, 2008     https://doi.org/10.3892/ijmm_00000025
  • Pages: 317-323
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Abstract

Glucosamine, a naturally occurring amino monosaccharide, is widely used to treat osteoarthritis in humans. Furthermore, glucosamine exhibits an anti-inflammatory action by inhibiting the activation of neutrophils, chondrocytes and synoviocytes. Recently, we revealed that glucosamine suppresses cytokine-induced activation of intestinal epithelial cells in vitro. In the present study therefore, we investigated whether glucosamine exhibits the anti-inflammatory effect in vivo, using dextran sulfate sodium (DSS)-induced colitis in rats, a model of inflammatory bowel diseases (IBD). The results indicated that glucosamine improved the clinical symptoms (evaluated by disease activity index), and suppressed colonic inflammation (evaluated by colon length and weight/length ratio) and tissue injury (evaluated by histological damage score) in DSS-induced colitis. Furthermore, glucosamine inhibited the activation of intestinal epithelial cells, as evidenced by the suppressed phosphorylation of NF-κB in the intestinal mucosa of DSS-induced colitis. Collectively, these observations suggest that glucosamine is likely to suppress the activation of intestinal epithelial cells in vivo, thereby possibly exhibiting anti-inflammatory action in a DSS-induced rat colitis model. Thus, glucosamine could prove to be a useful agent for IBD.

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September 2008
Volume 22 Issue 3

Print ISSN: 1107-3756
Online ISSN:1791-244X

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APA
Yomogida, S., Kojima, Y., Tsutsumi-Ishii, Y., Hua, J., Sakamoto, K., & Nagaoka, I. (2008). Glucosamine, a naturally occurring amino monosaccharide, suppresses dextran sulfate sodium-induced colitis in rats. International Journal of Molecular Medicine, 22, 317-323. https://doi.org/10.3892/ijmm_00000025
MLA
Yomogida, S., Kojima, Y., Tsutsumi-Ishii, Y., Hua, J., Sakamoto, K., Nagaoka, I."Glucosamine, a naturally occurring amino monosaccharide, suppresses dextran sulfate sodium-induced colitis in rats". International Journal of Molecular Medicine 22.3 (2008): 317-323.
Chicago
Yomogida, S., Kojima, Y., Tsutsumi-Ishii, Y., Hua, J., Sakamoto, K., Nagaoka, I."Glucosamine, a naturally occurring amino monosaccharide, suppresses dextran sulfate sodium-induced colitis in rats". International Journal of Molecular Medicine 22, no. 3 (2008): 317-323. https://doi.org/10.3892/ijmm_00000025