Hypolipidemic effect of Shoyu polysaccharides from soy sauce in animals and humans

  • Authors:
    • Makio Kobayashi
    • Norihiro Magishi
    • Hiroaki Matsushita
    • Tadaaki Hashimoto
    • Mayumi Fujimoto
    • Makoto Suzuki
    • Keisuke Tsuji
    • Masami Saito
    • Eishi Inoue
    • Yukako Yoshikawa
    • Toshiki Matsuura
  • View Affiliations

  • Published online on: October 1, 2008     https://doi.org/10.3892/ijmm_00000057
  • Pages: 565-570
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Abstract

Soy sauce (Shoyu) is a traditional Japanese fermented seasoning and is available worldwide. We investigated the effects of Shoyu polysaccharides (SPS) prepared from soy sauce on hyperlipidemia in vitro and in vivo. First, SPS inhibited pancreatic lipase. Second, in experiments with animals, it was found that SPS reduced serum triacylglycerol (TG) elevation induced by high-fat diets. Third, in a 2-week placebo-controlled parallel group study, healthy men (TG <150 mg/dl) were treated with 600 mg of SPS (n=5) or placebo (n=5) every day. After 2 weeks, serum TG elevation was significantly (P<0.05) lower in the SPS-treated group than in the placebo-treated group after 6 h of a high-fat diet. Fourth, in a 4-week randomized, double-blind, placebo-controlled parallel group study, hyperlipidemic men (TG >150 mg/dl) were treated with 600 mg of SPS (n=15) or placebo (n=15) daily. After 4 weeks, serum TG levels in the SPS-treated group were significantly (P<0.05) lower than the baseline (0 week). In conclusion, SPS of soy sauce reduce lipid absorption, and soy sauce is a potentially promising seasoning for the treatment of hyperlipidemia through food.

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October 2008
Volume 22 Issue 4

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Kobayashi M, Magishi N, Matsushita H, Hashimoto T, Fujimoto M, Suzuki M, Tsuji K, Saito M, Inoue E, Yoshikawa Y, Yoshikawa Y, et al: Hypolipidemic effect of Shoyu polysaccharides from soy sauce in animals and humans. Int J Mol Med 22: 565-570, 2008.
APA
Kobayashi, M., Magishi, N., Matsushita, H., Hashimoto, T., Fujimoto, M., Suzuki, M. ... Matsuura, T. (2008). Hypolipidemic effect of Shoyu polysaccharides from soy sauce in animals and humans. International Journal of Molecular Medicine, 22, 565-570. https://doi.org/10.3892/ijmm_00000057
MLA
Kobayashi, M., Magishi, N., Matsushita, H., Hashimoto, T., Fujimoto, M., Suzuki, M., Tsuji, K., Saito, M., Inoue, E., Yoshikawa, Y., Matsuura, T."Hypolipidemic effect of Shoyu polysaccharides from soy sauce in animals and humans". International Journal of Molecular Medicine 22.4 (2008): 565-570.
Chicago
Kobayashi, M., Magishi, N., Matsushita, H., Hashimoto, T., Fujimoto, M., Suzuki, M., Tsuji, K., Saito, M., Inoue, E., Yoshikawa, Y., Matsuura, T."Hypolipidemic effect of Shoyu polysaccharides from soy sauce in animals and humans". International Journal of Molecular Medicine 22, no. 4 (2008): 565-570. https://doi.org/10.3892/ijmm_00000057