Induction of tumor cell apoptosis by taurine Schiff base copper complex is associated with the inhibition of proteasomal activity

  • Authors:
    • Xia Zhang
    • Caifeng Bi
    • Yuhua Fan
    • Qiuzhi Cui
    • Di Chen
    • Yan Xiao
    • Q. Ping Dou
  • View Affiliations

  • Published online on: November 1, 2008     https://doi.org/10.3892/ijmm_00000072
  • Pages: 677-682
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Abstract

Schiff bases have been intensively investigated due to their antibacterial and antitumor properties. Copper is a cofactor essential for the tumor angiogenesis processes, whereas other transition metals are not. Consistently, high serum or tissue levels of copper were found in many types of human cancer including breast, prostate, colon, lung, and brain, supporting the idea that copper could be used as a novel selective target for cancer therapies. In the current study we hypothesize that a synthetic taurine Schiff base copper complex (Compound 1) could suppress tumor cell growth via the direct inhibition of proteasomal activity. Compound 1 potently inhibits the activity of purified 20S and 26S proteasome in human breast cancer MDA-MB-231 and leukemia Jurkat T cells. Inhibition of tumor cellular proteasomal activity by Compound 1 results in the accumulation of ubiquitinated protein and the proteasome target proteins p27 and Bax, followed by the induction of apoptosis. Our results strongly suggest that taurine Schiff base copper complexes, as potent proteasome inhibitors, have great potential to be developed into novel anticancer drugs.

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November 2008
Volume 22 Issue 5

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Zhang X, Bi C, Fan Y, Cui Q, Chen D, Xiao Y and Dou QP: Induction of tumor cell apoptosis by taurine Schiff base copper complex is associated with the inhibition of proteasomal activity. Int J Mol Med 22: 677-682, 2008
APA
Zhang, X., Bi, C., Fan, Y., Cui, Q., Chen, D., Xiao, Y., & Dou, Q.P. (2008). Induction of tumor cell apoptosis by taurine Schiff base copper complex is associated with the inhibition of proteasomal activity. International Journal of Molecular Medicine, 22, 677-682. https://doi.org/10.3892/ijmm_00000072
MLA
Zhang, X., Bi, C., Fan, Y., Cui, Q., Chen, D., Xiao, Y., Dou, Q. P."Induction of tumor cell apoptosis by taurine Schiff base copper complex is associated with the inhibition of proteasomal activity". International Journal of Molecular Medicine 22.5 (2008): 677-682.
Chicago
Zhang, X., Bi, C., Fan, Y., Cui, Q., Chen, D., Xiao, Y., Dou, Q. P."Induction of tumor cell apoptosis by taurine Schiff base copper complex is associated with the inhibition of proteasomal activity". International Journal of Molecular Medicine 22, no. 5 (2008): 677-682. https://doi.org/10.3892/ijmm_00000072