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PPARδ mediates IL15 metabolic actions in myotubes: Effects of hyperthermia

  • Authors:
    • Gemma Fuster
    • Sílvia Busquets
    • Maite Figueras
    • Elisabet Ametller
    • Cibely Cristine Fontes de Oliveira
    • Mireia Oliván
    • Paul A. Grimaldi
    • Josep M. Argilés
    • Francisco J. López-Soriano

  • View Affiliations

  • Published online on: July 1, 2009     https://doi.org/10.3892/ijmm_00000207
  • Pages: 63-68
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Abstract

C2C12 cells exposed to hyperthermia (41°C) experienced an increase in both protein synthesis and degradation. The addition of IL15 under hyperthermic conditions resulted in an important increase in protein synthesis with no changes in protein degradation, except when cells overexpressed PPARδ. The PPARδ agonist GW501516 exerted similar effects on protein synthesis to IL15. Expression of a mutant dominant negative form of PPARδ prevented the effect of the cytokine on protein synthesis, suggesting that this transcription factor is involved in the anabolic action of IL15. The present study also suggests that the effects of IL15 on lipid oxidation could be mediated by PPARδ.

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July 2009
Volume 24 Issue 1

Print ISSN: 1107-3756
Online ISSN:1791-244X

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  • Journal Metrics
  • Impact Factor: 5.4
  • Ranked Medicine Research and Experimental
    (total number of cites)
  • CiteScore: 10.7
  • CiteScore Rank: Q1: #35/328 Biochemistry, Genetics and Molecular Biology
  • Source Normalized Impact per Paper (SNIP): 0.994
  • SCImago Journal Rank (SJR): 0.922
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Spandidos Publications style
Fuster G, Busquets S, Figueras M, Ametller E, Fontes de Oliveira CC, Oliván M, Grimaldi PA, Argilés JM and López-Soriano FJ: PPARδ mediates IL15 metabolic actions in myotubes: Effects of hyperthermia. Int J Mol Med 24: 63-68, 2009
APA
Fuster, G., Busquets, S., Figueras, M., Ametller, E., Fontes de Oliveira, C.C., Oliván, M. ... López-Soriano, F.J. (2009). PPARδ mediates IL15 metabolic actions in myotubes: Effects of hyperthermia. International Journal of Molecular Medicine, 24, 63-68. https://doi.org/10.3892/ijmm_00000207
MLA
Fuster, G., Busquets, S., Figueras, M., Ametller, E., Fontes de Oliveira, C. C., Oliván, M., Grimaldi, P. A., Argilés, J. M., López-Soriano, F. J."PPARδ mediates IL15 metabolic actions in myotubes: Effects of hyperthermia". International Journal of Molecular Medicine 24.1 (2009): 63-68.
Chicago
Fuster, G., Busquets, S., Figueras, M., Ametller, E., Fontes de Oliveira, C. C., Oliván, M., Grimaldi, P. A., Argilés, J. M., López-Soriano, F. J."PPARδ mediates IL15 metabolic actions in myotubes: Effects of hyperthermia". International Journal of Molecular Medicine 24, no. 1 (2009): 63-68. https://doi.org/10.3892/ijmm_00000207