Role of angiotensin II type 1 receptor in cerebral aneurysm formation in rats

  • Authors:
    • Tomohiro Aoki
    • Masaki Nishimura
    • Hiroharu Kataoka
    • Ryota Ishibashi
    • Takashi Miyake
    • Yasushi Takagi
    • Ryuichi Morishita
    • Nobuo Hashimoto
  • View Affiliations

  • Published online on: Tuesday, September 1, 2009
  • Pages:353-359 DOI: 10.3892/ijmm_00000239
0

Abstract

Cerebral aneurysm (CA) causes catastrophic subarachnoid hemorrhage which is characterized by a high mortality and morbidity rate. CA is a common disease worldwide but to date there is no medical treatment against unruptured CAs. Thus, it is important to study the mechanisms of CA formation. Our previous report demonstrated that chronic inflammatory response in cerebral arterial bifurcation by hemodynamic stress deteriorated arterial walls and formed CA. Therefore, drugs with anti-inflammatory effects might effectively treat CA formation. As renin angiotensin system (RAS) is a major inflammatory cascade and related to various vascular diseases, including aortic aneurysms, the role of angiotensin (Ang) II type 1 receptor might contribute to the progression of CAs. However, in cerebral aneurysmal walls, Ang II type 1 receptor was not up-regulated. In addition, subcutaneously administered Ang II type 1 receptor blocker did not inhibit CA formation, nor inflammation in cerebral aneurysmal walls in rat models at a sub-suppressor dose. These results indicate that RAS might play a less important role in CA formation compared to aortic anuerysms or other vascular diseases. This suggests that there are different mechanisms between the pathogenesis of cereberal and aortic aneurysms.

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September 2009
Volume 24 Issue 3

Print ISSN: 1107-3756
Online ISSN:1791-244X

2015 Impact Factor: 2.348
Ranked #22/123 Medicine Research and Experimental
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APA
Aoki, T., Nishimura, M., Kataoka, H., Ishibashi, R., Miyake, T., Takagi, Y. ... Hashimoto, N. (2009). Role of angiotensin II type 1 receptor in cerebral aneurysm formation in rats. International Journal of Molecular Medicine, 24, 353-359. http://dx.doi.org/10.3892/ijmm_00000239
MLA
Aoki, T., Nishimura, M., Kataoka, H., Ishibashi, R., Miyake, T., Takagi, Y., Morishita, R., Hashimoto, N."Role of angiotensin II type 1 receptor in cerebral aneurysm formation in rats". International Journal of Molecular Medicine 24.3 (2009): 353-359.
Chicago
Aoki, T., Nishimura, M., Kataoka, H., Ishibashi, R., Miyake, T., Takagi, Y., Morishita, R., Hashimoto, N."Role of angiotensin II type 1 receptor in cerebral aneurysm formation in rats". International Journal of Molecular Medicine 24, no. 3 (2009): 353-359. http://dx.doi.org/10.3892/ijmm_00000239