Effects of local vibrations on skeletal muscle trophism in elderly people: mechanical, cellular, and molecular events

  • Authors:
    • Tiziana Pietrangelo
    • Rosa Mancinelli
    • Luana Toniolo
    • Lina Cancellara
    • Antonio Paoli
    • Cristina Puglielli
    • Pierpaolo Iodice
    • Christian Doria
    • Gerardo Bosco
    • Luigi D'Amelio
    • Guglielmo di Tano
    • Stefania Fulle
    • Raoul Saggini
    • Giorgio Fanò
    • Carlo Reggiani
  • View Affiliations

  • Published online on: October 1, 2009     https://doi.org/10.3892/ijmm_00000259
  • Pages: 503-512
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Abstract

Several studies have examined the effects of vibrations on muscle mass and performance in young healthy people. We studied the effects of vibrations on muscles of elderly male and female volunteers (65-85 years of age) diagnosed with sarcopenia. We applied mechanical vibrations locally (local vibrational training) to the thigh muscles at 300 Hz for a period of 12 weeks, starting with a session of 15 min stimulation once a week and increasing to three sessions of 15 min per week. Treated muscles displayed enhanced maximal isometric strength and increased content of fast MyHC-2X myosin. Single muscle fiber analysis did not show any change in cross-sectional area or in specific tension. Analysis of transcriptional profiles by microarray revealed changes in gene expression after 12 weeks of local vibrational training. In particular, pathways related with energy metabolism, sarcomeric protein balance and oxidative stress response were affected. We conclude that vibration treatment is effective in counteracting the loss of muscular strength associated with sarcopenia and the mode of action of vibration is based on cellular and molecular changes which do not include increase in fiber or muscle size.

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October 2009
Volume 24 Issue 4

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Pietrangelo T, Mancinelli R, Toniolo L, Cancellara L, Paoli A, Puglielli C, Iodice P, Doria C, Bosco G, D'Amelio L, D'Amelio L, et al: Effects of local vibrations on skeletal muscle trophism in elderly people: mechanical, cellular, and molecular events. Int J Mol Med 24: 503-512, 2009.
APA
Pietrangelo, T., Mancinelli, R., Toniolo, L., Cancellara, L., Paoli, A., Puglielli, C. ... Reggiani, C. (2009). Effects of local vibrations on skeletal muscle trophism in elderly people: mechanical, cellular, and molecular events. International Journal of Molecular Medicine, 24, 503-512. https://doi.org/10.3892/ijmm_00000259
MLA
Pietrangelo, T., Mancinelli, R., Toniolo, L., Cancellara, L., Paoli, A., Puglielli, C., Iodice, P., Doria, C., Bosco, G., D'Amelio, L., di Tano, G., Fulle, S., Saggini, R., Fanò, G., Reggiani, C."Effects of local vibrations on skeletal muscle trophism in elderly people: mechanical, cellular, and molecular events". International Journal of Molecular Medicine 24.4 (2009): 503-512.
Chicago
Pietrangelo, T., Mancinelli, R., Toniolo, L., Cancellara, L., Paoli, A., Puglielli, C., Iodice, P., Doria, C., Bosco, G., D'Amelio, L., di Tano, G., Fulle, S., Saggini, R., Fanò, G., Reggiani, C."Effects of local vibrations on skeletal muscle trophism in elderly people: mechanical, cellular, and molecular events". International Journal of Molecular Medicine 24, no. 4 (2009): 503-512. https://doi.org/10.3892/ijmm_00000259