Amelioration of asthmatic inflammation by an aqueous extract of Spinacia oleracea Linn

  • Authors:
    • Jin-Chul Heo
    • Chul-Hong Park
    • Hyun-Jin Lee
    • Si-Oh Kim
    • Tae-Ho Kim
    • Sang-Han Lee
  • View Affiliations

  • Published online on: March 1, 2010     https://doi.org/10.3892/ijmm_00000359
  • Pages: 409-414
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Abstract

Inflammation of the respiratory tract is a crucial process in immune diseases, including asthma, and atopic rhinitis. To establish whether an aqueous extract of Spinacia oleracea Linn (SoL) has a beneficial influence in terms of anti-asthmatic activity, we examined its effects on an ovalbumin-induced asthmatic model. Mice sensitized to ovalbumin were orally administered the SoL extract, and their lungs examined by hematoxylin and eosin staining to determine IL-4/13 cytokine expression. The SoL extract exerted strong anti-asthmatic effects by inducing a decrease in the CD4+ cell number, IL-4/13, and other molecular markers in the lung. Our results collectively indicate that the aqueous SoL extract ameliorates asthmatic symptoms effectively in a mouse ovalbumin-challenge model.

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March 2010
Volume 25 Issue 3

Print ISSN: 1107-3756
Online ISSN:1791-244X

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APA
Heo, J., Park, C., Lee, H., Kim, S., Kim, T., & Lee, S. (2010). Amelioration of asthmatic inflammation by an aqueous extract of Spinacia oleracea Linn. International Journal of Molecular Medicine, 25, 409-414. https://doi.org/10.3892/ijmm_00000359
MLA
Heo, J., Park, C., Lee, H., Kim, S., Kim, T., Lee, S."Amelioration of asthmatic inflammation by an aqueous extract of Spinacia oleracea Linn". International Journal of Molecular Medicine 25.3 (2010): 409-414.
Chicago
Heo, J., Park, C., Lee, H., Kim, S., Kim, T., Lee, S."Amelioration of asthmatic inflammation by an aqueous extract of Spinacia oleracea Linn". International Journal of Molecular Medicine 25, no. 3 (2010): 409-414. https://doi.org/10.3892/ijmm_00000359