Curcumin suppresses α-melanocyte stimulating hormone-stimulated melanogenesis in B16F10 cells

  • Authors:
    • Jun-Hyuk Lee
    • Ji-Yeon Jang
    • Cheol Park
    • Byung-Woo Kim
    • Yung-Hyun Choi
    • Byung-Tae Choi
  • View Affiliations

  • Published online on: July 1, 2010     https://doi.org/10.3892/ijmm_00000440
  • Pages: 101-106
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Abstract

The present study was designed to assess the potential inhibitory activity of curcumin on the α-melanocyte stimulating hormone (α-MSH)-stimulated melanogenesis signal pathway in B16F10 melanoma cells. The molecular mechanism of curcumin-induced inhibitory activity on the α-MSH-stimulated melanogenesis signal pathway, including expression of melanogenesis-related proteins and activation of melanogenesis-regulating proteins, was examined in B16F10 cells. Curcumin suppressed the cellular melanin contents and the tyrosinase activity in α-MSH-stimulated B16F10 cells. In addition, the expression of melanogenesis-related proteins such as microphthalmia-associated transcription factor (MITF), tyrosinase, and tyrosinase-related protein 1 and 2 was suppressed by curcumin in the α-MSH-stimulated B16F10 cells. Notably, a melanogenesis-regulating signal such as mitogen-activated protein kinase kinase (MEK)/extracellular signal-regulated kinase (ERK) or phosphatidylinositol 3-kinase (PI3K)/Akt was activated by curcumin in the B16F10 cells treated with or without α-MSH. The suppressive activity of curcumin on α-MSH-induced melanogenesis was down-regulated by PD98059 and by LY294002. Our results suggest that the suppressive activity of curcumin on α-MSH-stimulated melanogenesis may involve the down-regulation of MITF and its downstream signal pathway through the activation of MEK/ERK or PI3K/Akt.

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July 2010
Volume 26 Issue 1

Print ISSN: 1107-3756
Online ISSN:1791-244X

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APA
Lee, J., Jang, J., Park, C., Kim, B., Choi, Y., & Choi, B. (2010). Curcumin suppresses α-melanocyte stimulating hormone-stimulated melanogenesis in B16F10 cells . International Journal of Molecular Medicine, 26, 101-106. https://doi.org/10.3892/ijmm_00000440
MLA
Lee, J., Jang, J., Park, C., Kim, B., Choi, Y., Choi, B."Curcumin suppresses α-melanocyte stimulating hormone-stimulated melanogenesis in B16F10 cells ". International Journal of Molecular Medicine 26.1 (2010): 101-106.
Chicago
Lee, J., Jang, J., Park, C., Kim, B., Choi, Y., Choi, B."Curcumin suppresses α-melanocyte stimulating hormone-stimulated melanogenesis in B16F10 cells ". International Journal of Molecular Medicine 26, no. 1 (2010): 101-106. https://doi.org/10.3892/ijmm_00000440