Involvement of gicerin, a cell adhesion molecule, in a dermal autograft chicken model

  • Authors:
    • Yasuhiro Tsukamoto
    • Bin Kataoka
    • Kazuhide Adachi
    • Hidenori Kato
    • Marie Inai
    • Masaya Tsukamoto
    • Ekowati Handharyani
    • Eiichi Taira
  • View Affiliations

  • Published online on: November 1, 2010     https://doi.org/10.3892/ijmm_00000511
  • Pages: 661-666
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Abstract

Gicerin is a cell adhesion molecule in the immunoglobulin superfamily. This molecule has homophilic and heterophilic adhesive activities, binding to the neurite out-growth factor (NOF). We have previously reported that gicerin plays an important role in the development and regeneration as well as in the metastasis of tumors through its adhesive activities, mediating cell-cell and/or cell-extracellular matrix interactions. In this study, we investigated the involvement of gicerin in a dermal autograft chicken model. Gicerin and NOF were transiently present in the regenerating epithelia after the dermal graft transplantation. The treatment with an anti-gicerin polyclonal antibody, by placing drops onto the wounds, inhibited the adhesiveness of the grafts to the marginal skin. The chimeric protein of gicerin-IgG, gicerin-Fc, and NOF proteins promoted the regeneration of the grafts. These findings suggest the potential function of gicerin in dermal autografts, and gicerin and NOF proteins could help clinical improvement after transplantations.

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November 2010
Volume 26 Issue 5

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Tsukamoto Y, Kataoka B, Adachi K, Kato H, Inai M, Tsukamoto M, Handharyani E and Taira E: Involvement of gicerin, a cell adhesion molecule, in a dermal autograft chicken model . Int J Mol Med 26: 661-666, 2010.
APA
Tsukamoto, Y., Kataoka, B., Adachi, K., Kato, H., Inai, M., Tsukamoto, M. ... Taira, E. (2010). Involvement of gicerin, a cell adhesion molecule, in a dermal autograft chicken model . International Journal of Molecular Medicine, 26, 661-666. https://doi.org/10.3892/ijmm_00000511
MLA
Tsukamoto, Y., Kataoka, B., Adachi, K., Kato, H., Inai, M., Tsukamoto, M., Handharyani, E., Taira, E."Involvement of gicerin, a cell adhesion molecule, in a dermal autograft chicken model ". International Journal of Molecular Medicine 26.5 (2010): 661-666.
Chicago
Tsukamoto, Y., Kataoka, B., Adachi, K., Kato, H., Inai, M., Tsukamoto, M., Handharyani, E., Taira, E."Involvement of gicerin, a cell adhesion molecule, in a dermal autograft chicken model ". International Journal of Molecular Medicine 26, no. 5 (2010): 661-666. https://doi.org/10.3892/ijmm_00000511