Fundamentals of prions and their inactivation (Review)

  • Authors:
    • Akikazu Sakudo
    • Yasuhisa Ano
    • Takashi Onodera
    • Kayako Nitta
    • Hideharu Shintani
    • Kazuyoshi Ikuta
    • Yasuharu Tanaka
  • View Affiliations

  • Published online on: January 25, 2011     https://doi.org/10.3892/ijmm.2011.605
  • Pages: 483-489
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Abstract

Prion is an infectious particle composed of an abnormal isoform of the prion protein (PrPSc) and causes prion diseases such as bovine spongiform encephalopathy (BSE), Creutzfeldt-Jakob disease (CJD) and scrapie. Host cells express cellular prion protein (PrPC), which plays roles in normal functions such as anti-oxidative stress. PrPSc is derived from PrPC and produced by conformational conversion. Prion is notorious as a resistant pathogen, being difficult to inactivate with conventional sterilization procedures. Therefore, to prevent prion-caused iatrogenic diseases, the use of appropriate procedures to inactivate prions is important. For examples, alcohol treatment, autoclave (121˚C, 20 min) and γ-ray irradiation, which are used for disinfection, antisepsis or sterilization of viruses and bacteria, are not effective against prion. This is a fundamental review of prions and methods of their inactivation.

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April 2011
Volume 27 Issue 4

Print ISSN: 1107-3756
Online ISSN:1791-244X

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APA
Sakudo, A., Ano, Y., Onodera, T., Nitta, K., Shintani, H., Ikuta, K., & Tanaka, Y. (2011). Fundamentals of prions and their inactivation (Review). International Journal of Molecular Medicine, 27, 483-489. https://doi.org/10.3892/ijmm.2011.605
MLA
Sakudo, A., Ano, Y., Onodera, T., Nitta, K., Shintani, H., Ikuta, K., Tanaka, Y."Fundamentals of prions and their inactivation (Review)". International Journal of Molecular Medicine 27.4 (2011): 483-489.
Chicago
Sakudo, A., Ano, Y., Onodera, T., Nitta, K., Shintani, H., Ikuta, K., Tanaka, Y."Fundamentals of prions and their inactivation (Review)". International Journal of Molecular Medicine 27, no. 4 (2011): 483-489. https://doi.org/10.3892/ijmm.2011.605