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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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May 2011 Volume 27 Issue 5

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Article

Chemokine receptor 7 promotes cell migration and adhesion in metastatic squamous cell carcinoma of the head and neck by activating integrin αvβ3

  • Authors:
    • Peng Li
    • Fayu Liu
    • Liyan Sun
    • Zhenjin Zhao
    • Xue Ding
    • Dehao Shang
    • Zhongfei Xu
    • Changfu Sun

  • View Affiliations / Copyright

    Affiliations: Department of Oromaxillofacial-Head and Neck Surgery, School of Stomatology, China Medical University, Heping District, Shenyang, Liaoning 110002, P.R. China, Department of Oromaxillofacial-Head and Neck Surgery, School of Stomatology, China Medical University, 117 Nanjing Bei Jie, Heping District, Shenyang, Liaoning 110002, P.R. China
  • Pages: 679-687
    |
    Published online on: February 23, 2011
       https://doi.org/10.3892/ijmm.2011.628
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Abstract

The mechanisms leading to squamous cell carcinoma of the head and neck (SCCHN) metastasis are incompletely understood. Although evidence shows that the chemokine receptor 7 (CCR7) and its ligand CCL19 may regulate tumor dissemination, their role in SCCHN is not clearly defined. CCR7 has been shown to regulate integrins, which facilitate adhesion of cancer cells to and/or migration through the extracellular matrix (ECM). To investigate the relationship between CCR7 and integrin αvβ3 in metastatic SCCHN, we used adhesion and migration assays, immunofluorescence staining and western blotting to determine whether integrin αvβ3 can be activated by CCL19 in the metastatic SCCHN cell line PCI-37B, which was pre-incubated with CCL19 or the integrin αvβ3 inhibitor, IS201. Our results demonstrate that CCR7 favors PCI-37B cell adhesion and migration, induces reorganization of the actin cytoskeleton and induces integrin αvβ3 phosphorylation. The integrin αvβ3 inhibitor, IS201, blocked all of these effects. CCR7 and integrin αvβ3 expression significantly and positively correlated with tumor size, clinical stage and nodal metastasis. Taken together, our data indicate that CCR7 regulates cell adhesion and migration via integrin αvβ3 in metastatic SCCHN. These results should provide the groundwork for new strategies aimed at preventing SCCHN metastasis.

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Copy and paste a formatted citation
Spandidos Publications style
Li P, Liu F, Sun L, Zhao Z, Ding X, Shang D, Xu Z and Sun C: Chemokine receptor 7 promotes cell migration and adhesion in metastatic squamous cell carcinoma of the head and neck by activating integrin αvβ3. Int J Mol Med 27: 679-687, 2011.
APA
Li, P., Liu, F., Sun, L., Zhao, Z., Ding, X., Shang, D. ... Sun, C. (2011). Chemokine receptor 7 promotes cell migration and adhesion in metastatic squamous cell carcinoma of the head and neck by activating integrin αvβ3. International Journal of Molecular Medicine, 27, 679-687. https://doi.org/10.3892/ijmm.2011.628
MLA
Li, P., Liu, F., Sun, L., Zhao, Z., Ding, X., Shang, D., Xu, Z., Sun, C."Chemokine receptor 7 promotes cell migration and adhesion in metastatic squamous cell carcinoma of the head and neck by activating integrin αvβ3". International Journal of Molecular Medicine 27.5 (2011): 679-687.
Chicago
Li, P., Liu, F., Sun, L., Zhao, Z., Ding, X., Shang, D., Xu, Z., Sun, C."Chemokine receptor 7 promotes cell migration and adhesion in metastatic squamous cell carcinoma of the head and neck by activating integrin αvβ3". International Journal of Molecular Medicine 27, no. 5 (2011): 679-687. https://doi.org/10.3892/ijmm.2011.628
Copy and paste a formatted citation
x
Spandidos Publications style
Li P, Liu F, Sun L, Zhao Z, Ding X, Shang D, Xu Z and Sun C: Chemokine receptor 7 promotes cell migration and adhesion in metastatic squamous cell carcinoma of the head and neck by activating integrin αvβ3. Int J Mol Med 27: 679-687, 2011.
APA
Li, P., Liu, F., Sun, L., Zhao, Z., Ding, X., Shang, D. ... Sun, C. (2011). Chemokine receptor 7 promotes cell migration and adhesion in metastatic squamous cell carcinoma of the head and neck by activating integrin αvβ3. International Journal of Molecular Medicine, 27, 679-687. https://doi.org/10.3892/ijmm.2011.628
MLA
Li, P., Liu, F., Sun, L., Zhao, Z., Ding, X., Shang, D., Xu, Z., Sun, C."Chemokine receptor 7 promotes cell migration and adhesion in metastatic squamous cell carcinoma of the head and neck by activating integrin αvβ3". International Journal of Molecular Medicine 27.5 (2011): 679-687.
Chicago
Li, P., Liu, F., Sun, L., Zhao, Z., Ding, X., Shang, D., Xu, Z., Sun, C."Chemokine receptor 7 promotes cell migration and adhesion in metastatic squamous cell carcinoma of the head and neck by activating integrin αvβ3". International Journal of Molecular Medicine 27, no. 5 (2011): 679-687. https://doi.org/10.3892/ijmm.2011.628
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