Differential microRNA expression and identification of putative miRNA targets and pathways in head and neck cancers

  • Authors:
    • Α. Μ. Nurul-Syakima
    • C. Yoke-Kqueen
    • A. R. Sabariah
    • M. S. Shiran
    • A. Singh
    • L. Learn-Han
  • View Affiliations

  • Published online on: June 1, 2011     https://doi.org/10.3892/ijmm.2011.714
  • Pages: 327-336
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

MicroRNAs (miRNAs) are small noncoding RNAs that involved in various cancer-related cellular processes. Diverse studies on expression profiling of miRNAs have been performed and the data showed that some miRNAs are up-regulated or down-regulated in cancer. Until now, there are no data published on the miRNA expression in head and neck cancers from Malaysia. Hence, this study aimed to investigate potentially crucial miRNAs in head and neck cancer patients from Malaysian populations. A global miRNA profiling was performed on 12 samples of head and neck cancer tissue using microarray analysis followed by validation using real-time RT-PCR. Microarray analysis identified 10 miRNAs that could distinguish malignant head and neck cancer lesions from normal tissues; 7 miRNAs (hsa-miR-181a-2*, hsa-miR-29b-1*, hsa-miR-181a, hsa-miR-181b, hsa-miR-744, hsa-miR-1271 and hsa-miR-221*) were up-regulated while 3 miRNAs (hsa-miR-141, hsa-miR-95 and hsa-miR-101) were down-regulated. These miRNAs may contribute in a simple profiling strategy to identify individuals at higher risk of developing head and neck cancers, thus helping in the elucidation of the molecular mechanisms involved in head and neck cancer pathogenesis.

Related Articles

Journal Cover

September 2011
Volume 28 Issue 3

Print ISSN: 1107-3756
Online ISSN:1791-244X

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Nurul-Syakima ΑΜ, Yoke-Kqueen C, Sabariah AR, Shiran MS, Singh A and Learn-Han L: Differential microRNA expression and identification of putative miRNA targets and pathways in head and neck cancers. Int J Mol Med 28: 327-336, 2011
APA
Nurul-Syakima, Α.Μ., Yoke-Kqueen, C., Sabariah, A.R., Shiran, M.S., Singh, A., & Learn-Han, L. (2011). Differential microRNA expression and identification of putative miRNA targets and pathways in head and neck cancers. International Journal of Molecular Medicine, 28, 327-336. https://doi.org/10.3892/ijmm.2011.714
MLA
Nurul-Syakima, Α. Μ., Yoke-Kqueen, C., Sabariah, A. R., Shiran, M. S., Singh, A., Learn-Han, L."Differential microRNA expression and identification of putative miRNA targets and pathways in head and neck cancers". International Journal of Molecular Medicine 28.3 (2011): 327-336.
Chicago
Nurul-Syakima, Α. Μ., Yoke-Kqueen, C., Sabariah, A. R., Shiran, M. S., Singh, A., Learn-Han, L."Differential microRNA expression and identification of putative miRNA targets and pathways in head and neck cancers". International Journal of Molecular Medicine 28, no. 3 (2011): 327-336. https://doi.org/10.3892/ijmm.2011.714