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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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October 2011 Volume 28 Issue 4

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

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Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Article Open Access

Loss of imprinting and aberrant methylation of IGF2 in placentas from pregnancies complicated with fetal growth restriction

  • Authors:
    • Ourania Koukoura
    • Stavros Sifakis
    • Giannoula Soufla
    • Apostolos Zaravinos
    • Sophia Apostolidou
    • Allison Jones
    • Martin Widschwendter
    • Demetrios A. Spandidos

  • View Affiliations / Copyright

    Affiliations: Department of Obstetrics and Gynaecology, University Hospital of Heraklion, Heraklion, Crete, Greece, Laboratory of Virology, Medical School, University of Crete, P.O. Box 1527, Heraklion 710 03, Crete, Greece
  • Pages: 481-487
    |
    Published online on: July 19, 2011
       https://doi.org/10.3892/ijmm.2011.754
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Abstract

The objective of this study was to investigate the hypothesis that the altered epigenetic mechanisms that regulate IGF2 imprinting in placentas from fetal growth restricted (FGR) pregnancies affect IGF2 expression leading to impaired fetal growth. We investigated gene transcription, genotyping and the methylation patterns of IGF2 from 31 and 17 placentas from FGR-complicated and normal pregnancies, respectively. A statistically significant decrease in IGF2 mRNA levels was observed in the placentas from the FGR pregnancies. Loss of imprinting (LOI) was only detected in the abnormal placentas. The evaluation of the percentage of the methylated reference (PMR) of two different potentially differentially methylated regions (DMR) demonstrated significant PMR values in both sites for the normal and FGR pregnancies with no significant differences. Our results suggest the involvement of the IGF2 imprinted gene in placental function and fetal growth and the possible association of epigenetic alterations with the pathophysiology of fetal growth restriction.

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Copy and paste a formatted citation
Spandidos Publications style
Koukoura O, Sifakis S, Soufla G, Zaravinos A, Apostolidou S, Jones A, Widschwendter M and Spandidos DA: Loss of imprinting and aberrant methylation of IGF2 in placentas from pregnancies complicated with fetal growth restriction. Int J Mol Med 28: 481-487, 2011.
APA
Koukoura, O., Sifakis, S., Soufla, G., Zaravinos, A., Apostolidou, S., Jones, A. ... Spandidos, D.A. (2011). Loss of imprinting and aberrant methylation of IGF2 in placentas from pregnancies complicated with fetal growth restriction. International Journal of Molecular Medicine, 28, 481-487. https://doi.org/10.3892/ijmm.2011.754
MLA
Koukoura, O., Sifakis, S., Soufla, G., Zaravinos, A., Apostolidou, S., Jones, A., Widschwendter, M., Spandidos, D. A."Loss of imprinting and aberrant methylation of IGF2 in placentas from pregnancies complicated with fetal growth restriction". International Journal of Molecular Medicine 28.4 (2011): 481-487.
Chicago
Koukoura, O., Sifakis, S., Soufla, G., Zaravinos, A., Apostolidou, S., Jones, A., Widschwendter, M., Spandidos, D. A."Loss of imprinting and aberrant methylation of IGF2 in placentas from pregnancies complicated with fetal growth restriction". International Journal of Molecular Medicine 28, no. 4 (2011): 481-487. https://doi.org/10.3892/ijmm.2011.754
Copy and paste a formatted citation
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Spandidos Publications style
Koukoura O, Sifakis S, Soufla G, Zaravinos A, Apostolidou S, Jones A, Widschwendter M and Spandidos DA: Loss of imprinting and aberrant methylation of IGF2 in placentas from pregnancies complicated with fetal growth restriction. Int J Mol Med 28: 481-487, 2011.
APA
Koukoura, O., Sifakis, S., Soufla, G., Zaravinos, A., Apostolidou, S., Jones, A. ... Spandidos, D.A. (2011). Loss of imprinting and aberrant methylation of IGF2 in placentas from pregnancies complicated with fetal growth restriction. International Journal of Molecular Medicine, 28, 481-487. https://doi.org/10.3892/ijmm.2011.754
MLA
Koukoura, O., Sifakis, S., Soufla, G., Zaravinos, A., Apostolidou, S., Jones, A., Widschwendter, M., Spandidos, D. A."Loss of imprinting and aberrant methylation of IGF2 in placentas from pregnancies complicated with fetal growth restriction". International Journal of Molecular Medicine 28.4 (2011): 481-487.
Chicago
Koukoura, O., Sifakis, S., Soufla, G., Zaravinos, A., Apostolidou, S., Jones, A., Widschwendter, M., Spandidos, D. A."Loss of imprinting and aberrant methylation of IGF2 in placentas from pregnancies complicated with fetal growth restriction". International Journal of Molecular Medicine 28, no. 4 (2011): 481-487. https://doi.org/10.3892/ijmm.2011.754
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