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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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November 2011 Volume 28 Issue 5

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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November 2011 Volume 28 Issue 5

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Article

Overexpression of the small GTPase Arl4D suppresses adipogenesis

  • Authors:
    • Jiahua Yu
    • Sun-O Ka
    • Kang-Beom Kwon
    • Sang-Myeong Lee
    • Jin-Woo Park
    • Byung-Hyun Park

  • View Affiliations

    Affiliations: Department of Biochemistry, Research Institute for Endocrine Sciences, and Diabetes Research Center, Chonbuk National University Medical School, Jeonju, Jeonbuk 561-756, Republic of Korea, Department of Bioche­mistry, Chonbuk National University Medical School, San 2-20, Geumam-dong, Dukjin-gu, Jeonju, Jeonbuk 561-756, Republic of Korea
  • Published online on: July 15, 2011     https://doi.org/10.3892/ijmm.2011.751
  • Pages: 793-798
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Abstract

Arl4D is a developmentally-regulated member of the ADP-ribosylation factor/ARF-like protein (ARF/Arl) family of Ras-related GTPases. Although Arl4 protein is reported to be expressed in adipose tissue, the function of Arl4D is unknown. To investigate the potential role of Arl4D in adipogenesis, we examined Arl4D expression during adipocyte differentiation and the effects of Arl4D overexpression on adipogenesis. Arl4D protein increased early in adipogenesis, with the highest expression at 4 h after adipogenesis initiation, followed by a decrease thereafter. Overexpression of Arl4D in 3T3-L1 cells potently inhibited their ability to differentiate and accumulate lipid, and reduced the expression of adipogenic genes. Furthermore, treatment with valproic acid, an Arl4D inducer, suppressed adipogenesis. These results suggest that rapid reduction of Arl4D is required for adipogenesis to proceed.

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Copy and paste a formatted citation
Spandidos Publications style
Yu J, Ka S, Kwon K, Lee S, Park J and Park B: Overexpression of the small GTPase Arl4D suppresses adipogenesis. Int J Mol Med 28: 793-798, 2011.
APA
Yu, J., Ka, S., Kwon, K., Lee, S., Park, J., & Park, B. (2011). Overexpression of the small GTPase Arl4D suppresses adipogenesis. International Journal of Molecular Medicine, 28, 793-798. https://doi.org/10.3892/ijmm.2011.751
MLA
Yu, J., Ka, S., Kwon, K., Lee, S., Park, J., Park, B."Overexpression of the small GTPase Arl4D suppresses adipogenesis". International Journal of Molecular Medicine 28.5 (2011): 793-798.
Chicago
Yu, J., Ka, S., Kwon, K., Lee, S., Park, J., Park, B."Overexpression of the small GTPase Arl4D suppresses adipogenesis". International Journal of Molecular Medicine 28, no. 5 (2011): 793-798. https://doi.org/10.3892/ijmm.2011.751
Copy and paste a formatted citation
x
Spandidos Publications style
Yu J, Ka S, Kwon K, Lee S, Park J and Park B: Overexpression of the small GTPase Arl4D suppresses adipogenesis. Int J Mol Med 28: 793-798, 2011.
APA
Yu, J., Ka, S., Kwon, K., Lee, S., Park, J., & Park, B. (2011). Overexpression of the small GTPase Arl4D suppresses adipogenesis. International Journal of Molecular Medicine, 28, 793-798. https://doi.org/10.3892/ijmm.2011.751
MLA
Yu, J., Ka, S., Kwon, K., Lee, S., Park, J., Park, B."Overexpression of the small GTPase Arl4D suppresses adipogenesis". International Journal of Molecular Medicine 28.5 (2011): 793-798.
Chicago
Yu, J., Ka, S., Kwon, K., Lee, S., Park, J., Park, B."Overexpression of the small GTPase Arl4D suppresses adipogenesis". International Journal of Molecular Medicine 28, no. 5 (2011): 793-798. https://doi.org/10.3892/ijmm.2011.751
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