Open Access

Identification of immunity-related genes in prostate cancer and potential role of the ETS family of transcription factors in their regulation

  • Authors:
    • David Adler
    • Andreas Lindstrot
    • Jörg Ellinger
    • Sebastian Rogenhofer
    • Reinhard Buettner
    • Nicolas Wernert
  • View Affiliations

  • Published online on: August 10, 2011     https://doi.org/10.3892/ijmm.2011.771
  • Pages: 799-807
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

The role of the immune response in tumor progression, and disease outcome is still debated, and a lack of knowledge of the immune defenses in prostate cancer still exists. In addition, the ETS family of transcription factors which is involved in translocations frequently found in prostate cancer is reported to be essential for the regulation of immunity-related genes. In order to identify immunity-related genes in prostate cancer, we performed two microarrays using RNA extracted from laser microdissected glands of the normal prostate proper (or the peripheral zone) and moderately and poorly differentiated prostate carcinomas from patients who had undergone radical prostatectomy. Many differentially expressed genes were found, however, only immunity-related genes (B cell, innate, and T cell immunity) with an expression of more than 10-fold increase or decrease and a P<0.01 between the moderately differentiated tumors and the normal glands, and the poorly differentiated tumors and the normal glands were considered significant. Based on these two microarrays, we identified a set of 37 genes that were up- or down-regulated in tumors (moderately and poorly differentiated) compared to the normal glands. Analysis of these genes revealed, strikingly, that 31/37 of these genes have potential binding sites within their promoter regions for members of the ETS family of transcription factors, and some are reported to be targets of ETS members. These findings identified immunity-related genes in prostate cancer, and provided insights into their potential regulation, which may lead to a better early detection, immunotherapy, and therapeutic drug treatment of this disease. Unraveling the dynamics of the ETS-immunity-related genes will provide an invaluable insight into understanding prostate cancer immunology.

Related Articles

Journal Cover

November 2011
Volume 28 Issue 5

Print ISSN: 1107-3756
Online ISSN:1791-244X

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Adler D, Lindstrot A, Ellinger J, Rogenhofer S, Buettner R and Wernert N: Identification of immunity-related genes in prostate cancer and potential role of the ETS family of transcription factors in their regulation. Int J Mol Med 28: 799-807, 2011.
APA
Adler, D., Lindstrot, A., Ellinger, J., Rogenhofer, S., Buettner, R., & Wernert, N. (2011). Identification of immunity-related genes in prostate cancer and potential role of the ETS family of transcription factors in their regulation. International Journal of Molecular Medicine, 28, 799-807. https://doi.org/10.3892/ijmm.2011.771
MLA
Adler, D., Lindstrot, A., Ellinger, J., Rogenhofer, S., Buettner, R., Wernert, N."Identification of immunity-related genes in prostate cancer and potential role of the ETS family of transcription factors in their regulation". International Journal of Molecular Medicine 28.5 (2011): 799-807.
Chicago
Adler, D., Lindstrot, A., Ellinger, J., Rogenhofer, S., Buettner, R., Wernert, N."Identification of immunity-related genes in prostate cancer and potential role of the ETS family of transcription factors in their regulation". International Journal of Molecular Medicine 28, no. 5 (2011): 799-807. https://doi.org/10.3892/ijmm.2011.771