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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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January 2012 Volume 29 Issue 1

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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January 2012 Volume 29 Issue 1

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Article

Suppression of α-MSH and IBMX-induced melanogenesis by cordycepin via inhibition of CREB and MITF, and activation of PI3K/Akt and ERK-dependent mechanisms

  • Authors:
    • Mei Ling Jin
    • Sun Young Park
    • Young Hun Kim
    • Geuntae Park
    • Hong-Joo Son
    • Sang-Joon Lee

  • View Affiliations / Copyright

    Affiliations: Department of Microbiology, Pusan National University, Busan, Republic of Korea, Department of Micro­biology, Pusan National University, Busan 609-735, Republic of Korea
  • Pages: 119-124
    |
    Published online on: October 3, 2011
       https://doi.org/10.3892/ijmm.2011.807
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Abstract

Cordycepin has been a traditional medicine in China and Korea for centuries. This study explored the inhibitory effect of cordycepin on melanogenesis and the relative molecular mechanisms. Cordycepin inhibited melanin synthesis-related enzymes, such as tyrosinase, tyrosinase-related protein-1 (TRP1) and tyrosinase-related protein-2 (TRP2). α-MSH and IBMX were reported as melanin synthesis enhancers. Both of them could increase intracellular melanin synthesis by activation of the microphthalmia-associated transcription factor (MITF) signaling pathway. In the MITF pathway, the phosphorylation of cAMP related binding protein (CREB) activated the transcription of MITF, resulting in increasing melanin synthesis. Cordycepin also decreased the phosphorylation of CREB induced by α-MSH and IBMX in B16F10 melanoma cells. Accordingly, cordycepin inhibited melanogenesis signaling pathways by activating ERK and AKT signaling pathways to regulate the suppression of MITF and its downstream pathways including tyrosinase, TRP1 and TRP2. These results indicate the role of cordycepin as a potent depigmenting agent for cosmetics.

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Copy and paste a formatted citation
Spandidos Publications style
Jin ML, Park SY, Kim YH, Park G, Son H and Lee S: Suppression of α-MSH and IBMX-induced melanogenesis by cordycepin via inhibition of CREB and MITF, and activation of PI3K/Akt and ERK-dependent mechanisms. Int J Mol Med 29: 119-124, 2012.
APA
Jin, M.L., Park, S.Y., Kim, Y.H., Park, G., Son, H., & Lee, S. (2012). Suppression of α-MSH and IBMX-induced melanogenesis by cordycepin via inhibition of CREB and MITF, and activation of PI3K/Akt and ERK-dependent mechanisms. International Journal of Molecular Medicine, 29, 119-124. https://doi.org/10.3892/ijmm.2011.807
MLA
Jin, M. L., Park, S. Y., Kim, Y. H., Park, G., Son, H., Lee, S."Suppression of α-MSH and IBMX-induced melanogenesis by cordycepin via inhibition of CREB and MITF, and activation of PI3K/Akt and ERK-dependent mechanisms". International Journal of Molecular Medicine 29.1 (2012): 119-124.
Chicago
Jin, M. L., Park, S. Y., Kim, Y. H., Park, G., Son, H., Lee, S."Suppression of α-MSH and IBMX-induced melanogenesis by cordycepin via inhibition of CREB and MITF, and activation of PI3K/Akt and ERK-dependent mechanisms". International Journal of Molecular Medicine 29, no. 1 (2012): 119-124. https://doi.org/10.3892/ijmm.2011.807
Copy and paste a formatted citation
x
Spandidos Publications style
Jin ML, Park SY, Kim YH, Park G, Son H and Lee S: Suppression of α-MSH and IBMX-induced melanogenesis by cordycepin via inhibition of CREB and MITF, and activation of PI3K/Akt and ERK-dependent mechanisms. Int J Mol Med 29: 119-124, 2012.
APA
Jin, M.L., Park, S.Y., Kim, Y.H., Park, G., Son, H., & Lee, S. (2012). Suppression of α-MSH and IBMX-induced melanogenesis by cordycepin via inhibition of CREB and MITF, and activation of PI3K/Akt and ERK-dependent mechanisms. International Journal of Molecular Medicine, 29, 119-124. https://doi.org/10.3892/ijmm.2011.807
MLA
Jin, M. L., Park, S. Y., Kim, Y. H., Park, G., Son, H., Lee, S."Suppression of α-MSH and IBMX-induced melanogenesis by cordycepin via inhibition of CREB and MITF, and activation of PI3K/Akt and ERK-dependent mechanisms". International Journal of Molecular Medicine 29.1 (2012): 119-124.
Chicago
Jin, M. L., Park, S. Y., Kim, Y. H., Park, G., Son, H., Lee, S."Suppression of α-MSH and IBMX-induced melanogenesis by cordycepin via inhibition of CREB and MITF, and activation of PI3K/Akt and ERK-dependent mechanisms". International Journal of Molecular Medicine 29, no. 1 (2012): 119-124. https://doi.org/10.3892/ijmm.2011.807
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