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DNA damage induced by Salmonella test-negative carcinogens through the formation of oxygen and nitrogen-derived reactive species (review).

  • Authors:
    • S Kawanishi
    • Y Hiraku
    • S Inoue

  • View Affiliations

  • Published online on: February 1, 1999     https://doi.org/10.3892/ijmm.3.2.169
  • Pages: 169-243
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
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Abstract

High levels of active oxygen species generated by carcinogenic chemicals can cause DNA damage, which may lead to carcinogenesis. We have investigated the characteristics and mechanisms of DNA damage induced by some carcinogens. Here we show our experimental results and propose the possible mechanisms of DNA damage through a) NADH-dependent and b) manganese-dependent formation of reactive oxygen species. We also discuss the mechanism of c) DNA damage induced by nitric oxide and peroxynitrite.

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Journal Cover

Feb 1999
Volume 3 Issue 2

Print ISSN: 1107-3756
Online ISSN:1791-244X

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  • Journal Metrics
  • Impact Factor: 5.4
  • Ranked Medicine Research and Experimental
    (total number of cites)
  • CiteScore: 10.7
  • CiteScore Rank: Q1: #35/328 Biochemistry, Genetics and Molecular Biology
  • Source Normalized Impact per Paper (SNIP): 0.994
  • SCImago Journal Rank (SJR): 0.922
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Spandidos Publications style
Kawanishi S, Hiraku Y and Inoue S: DNA damage induced by Salmonella test-negative carcinogens through the formation of oxygen and nitrogen-derived reactive species (review).. Int J Mol Med 3: 169-243, 1999
APA
Kawanishi, S., Hiraku, Y., & Inoue, S. (1999). DNA damage induced by Salmonella test-negative carcinogens through the formation of oxygen and nitrogen-derived reactive species (review).. International Journal of Molecular Medicine, 3, 169-243. https://doi.org/10.3892/ijmm.3.2.169
MLA
Kawanishi, S., Hiraku, Y., Inoue, S."DNA damage induced by Salmonella test-negative carcinogens through the formation of oxygen and nitrogen-derived reactive species (review).". International Journal of Molecular Medicine 3.2 (1999): 169-243.
Chicago
Kawanishi, S., Hiraku, Y., Inoue, S."DNA damage induced by Salmonella test-negative carcinogens through the formation of oxygen and nitrogen-derived reactive species (review).". International Journal of Molecular Medicine 3, no. 2 (1999): 169-243. https://doi.org/10.3892/ijmm.3.2.169