The mouse interferon-gamma transgene chronic hepatitis model (Review).

  • Authors:
    • T Okamoto
    • K Yamamura
    • O Hino
  • View Affiliations

  • Published online on: May 1, 1999     https://doi.org/10.3892/ijmm.3.5.517
  • Pages: 517-537
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Abstract

Acute hepatitis models are widely used for the evaluation of drugs for liver disease or for basic research on hepatitis. However, it is difficult to produce similar liver conditions to human chronic hepatitis with an acute hepatitis model. The interferon-gamma (IFN-gamma) transgenic mouse, which carries the mouse IFN-gamma gene, strongly expresses the IFN-gamma gene in the liver and develops chronic hepatitis from the age of 6-10 weeks. We found that the hepatitis in this mouse reflects human chronic hepatitis at least in the following points, i) infiltration by lymphoid cells into the portal areas and necroinflammation in the lobules, and ii) expression of Fas antigen and Fas ligand mRNAs in the liver. Furthermore, the induction of CPP32-like protease activity in the transgenic mouse liver suggests the involvement of this protease activity in the development of chronic hepatitis.

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May 1999
Volume 3 Issue 5

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Okamoto T, Yamamura K and Hino O: The mouse interferon-gamma transgene chronic hepatitis model (Review).. Int J Mol Med 3: 517-537, 1999
APA
Okamoto, T., Yamamura, K., & Hino, O. (1999). The mouse interferon-gamma transgene chronic hepatitis model (Review).. International Journal of Molecular Medicine, 3, 517-537. https://doi.org/10.3892/ijmm.3.5.517
MLA
Okamoto, T., Yamamura, K., Hino, O."The mouse interferon-gamma transgene chronic hepatitis model (Review).". International Journal of Molecular Medicine 3.5 (1999): 517-537.
Chicago
Okamoto, T., Yamamura, K., Hino, O."The mouse interferon-gamma transgene chronic hepatitis model (Review).". International Journal of Molecular Medicine 3, no. 5 (1999): 517-537. https://doi.org/10.3892/ijmm.3.5.517