Expression of hepatocyte growth factor/scatter factor and its receptor c-Met in brain tumors: evidence for a role in progression of astrocytic tumors (Review).

  • Authors:
    • T Moriyama
    • H Kataoka
    • M Koono
    • S Wakisaka
  • View Affiliations

  • Published online on: May 1, 1999     https://doi.org/10.3892/ijmm.3.5.531
  • Pages: 531-537
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Abstract

Hepatocyte growth factor (HGF) is a multifunctional cytokine which is believed to have important roles in tissue development and regeneration, and tumor progression. It is indistinguishable from scatter factor (SF), a motility factor. HGF/SF is believed to be a mesenchymal cell-derived cytokine acting for epithelial cells bearing its receptor tyrosine kinase, c-Met. Recently, we found that glioblastoma multiforme (GBM), a highly malignant brain tumor of astrocytic origin, concomitantly express HGF/SF and c-Met. This finding indicates a presence of autocrine loop of HGF/SF signaling pathway in GBM. Moreover, GBM cells also co-express HGF activator, a recently identified serine proteinase having efficient HGF/SF activating activity. The expression of HGF/SF and c-Met was low or hardly detectable in low-grade astrocytoma, and c-Met immunoreactivity was correlated with the histological grade of the tumor suggesting that the creation of HGF/SF autocrine loop occurs along with the progression of astrocytic brain tumors. Experimental evidence indicated that HGF/SF exhibits potent migration/invasion-inducing activity for GBM cells bearing c-Met receptor. It is also a significant angiogenesis factor in GBM, and may serve as a cellular growth factor for certain GBM cells. These lines of evidence suggest that HGF/SF signaling pathway may serve as a promising new target of therapeutic intervention of GBM.

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May 1999
Volume 3 Issue 5

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Moriyama T, Kataoka H, Koono M and Wakisaka S: Expression of hepatocyte growth factor/scatter factor and its receptor c-Met in brain tumors: evidence for a role in progression of astrocytic tumors (Review).. Int J Mol Med 3: 531-537, 1999
APA
Moriyama, T., Kataoka, H., Koono, M., & Wakisaka, S. (1999). Expression of hepatocyte growth factor/scatter factor and its receptor c-Met in brain tumors: evidence for a role in progression of astrocytic tumors (Review).. International Journal of Molecular Medicine, 3, 531-537. https://doi.org/10.3892/ijmm.3.5.531
MLA
Moriyama, T., Kataoka, H., Koono, M., Wakisaka, S."Expression of hepatocyte growth factor/scatter factor and its receptor c-Met in brain tumors: evidence for a role in progression of astrocytic tumors (Review).". International Journal of Molecular Medicine 3.5 (1999): 531-537.
Chicago
Moriyama, T., Kataoka, H., Koono, M., Wakisaka, S."Expression of hepatocyte growth factor/scatter factor and its receptor c-Met in brain tumors: evidence for a role in progression of astrocytic tumors (Review).". International Journal of Molecular Medicine 3, no. 5 (1999): 531-537. https://doi.org/10.3892/ijmm.3.5.531