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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
Journal Cover
Jun 1999 Volume 3 Issue 6

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Jun 1999 Volume 3 Issue 6

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Article

IAPP as a regulator of glucose homeostasis and pancreatic hormone secretion (review).

  • Authors:
    • E Karlsson
  • View Affiliations / Copyright

    Affiliations: Department of Medical Cell Biology, Uppsala University, Biomedicum, SE-751 23 Uppsala, Sweden.
  • Pages: 577-661
    |
    Published online on: June 1, 1999
       https://doi.org/10.3892/ijmm.3.6.577
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Abstract

IAPP is a 37-amino acid peptide that is predominantly expressed in pancreatic beta cells. Despite co-secretion from islets the relative amounts of IAPP and insulin may vary. Since IAPP was first described as the major peptide constituent of amyloid in the islets of Langerhans of subjects with type 2 diabetes and insulinoma, many studies have been devoted to investigating the role of IAPP in formation of amyloid deposits and in diabetes pathogenesis. However, there is growing evidence for IAPP as an active islet hormone in addition to insulin and glucagon in glucose metabolic control. An inhibitory effect is seen by IAPP on gastric emptying, glycogen synthesis in skeletal muscle, islet insulin and glucagon secretion, whereas a stimulatory effect is seen on hepatic gluconeogenesis.

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Copy and paste a formatted citation
Spandidos Publications style
Karlsson E: IAPP as a regulator of glucose homeostasis and pancreatic hormone secretion (review).. Int J Mol Med 3: 577-661, 1999.
APA
Karlsson, E. (1999). IAPP as a regulator of glucose homeostasis and pancreatic hormone secretion (review).. International Journal of Molecular Medicine, 3, 577-661. https://doi.org/10.3892/ijmm.3.6.577
MLA
Karlsson, E."IAPP as a regulator of glucose homeostasis and pancreatic hormone secretion (review).". International Journal of Molecular Medicine 3.6 (1999): 577-661.
Chicago
Karlsson, E."IAPP as a regulator of glucose homeostasis and pancreatic hormone secretion (review).". International Journal of Molecular Medicine 3, no. 6 (1999): 577-661. https://doi.org/10.3892/ijmm.3.6.577
Copy and paste a formatted citation
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Spandidos Publications style
Karlsson E: IAPP as a regulator of glucose homeostasis and pancreatic hormone secretion (review).. Int J Mol Med 3: 577-661, 1999.
APA
Karlsson, E. (1999). IAPP as a regulator of glucose homeostasis and pancreatic hormone secretion (review).. International Journal of Molecular Medicine, 3, 577-661. https://doi.org/10.3892/ijmm.3.6.577
MLA
Karlsson, E."IAPP as a regulator of glucose homeostasis and pancreatic hormone secretion (review).". International Journal of Molecular Medicine 3.6 (1999): 577-661.
Chicago
Karlsson, E."IAPP as a regulator of glucose homeostasis and pancreatic hormone secretion (review).". International Journal of Molecular Medicine 3, no. 6 (1999): 577-661. https://doi.org/10.3892/ijmm.3.6.577
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