Open Access

Interleukin-6, but not the interleukin-6 receptor plays a role in recovery from dextran sodium sulfate-induced colitis

  • Authors:
    • Jan Sommer
    • Erika Engelowski
    • Paul Baran
    • Christoph Garbers
    • Doreen M. Floss
    • Jürgen Scheller
  • View Affiliations

  • Published online on: June 27, 2014     https://doi.org/10.3892/ijmm.2014.1825
  • Pages: 651-660
  • Copyright: © Sommer et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY_NC 3.0].

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Abstract

Interleukin (IL)-6-deficient, but not IL-6 receptor (IL-6R)‑deficient mice present with a delayed skin wound healing phenotype. Since IL-6 solely signals via the IL-6R and glycoprotein 130 (gp130), Il-6r-deficient mice are expected to exhibit a similar phenotype as Il-6-deficient mice. However, p28 (IL-30) and ciliary neurotrophic factor (CNTF) have been identified as additional low‑affinity ligands of the IL-6R/gp130/LIFR complex. IL-6 plays an inflammatory and regenerative role in inflammatory bowel disease (IBD). In the present study, we compared Il-6r-deficient mice with mice treated with neutralizing IL-6 monoclonal antibody (mAb) in a model of dextran sodium sulfate (DSS)-induced colitis. Our results, in agreement with those of previous reports, demonstrated that IL-6 mAbs slightly attenuated DSS-induced colitis during the regeneration phase. Il-6r-deficient mice and mice with tissue-specific deletion of the Il-6r in the myeloid cell lineage (LysMCre) with acute and chronic DSS-induced colitis were, however, indistinguishable from wild-type mice. Our data suggest that IL-6 and IL-6R have an additional role in colitis, apart from the IL-6/IL-6R classic and trans-signaling.
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September-2014
Volume 34 Issue 3

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Sommer J, Engelowski E, Baran P, Garbers C, Floss DM and Scheller J: Interleukin-6, but not the interleukin-6 receptor plays a role in recovery from dextran sodium sulfate-induced colitis. Int J Mol Med 34: 651-660, 2014.
APA
Sommer, J., Engelowski, E., Baran, P., Garbers, C., Floss, D.M., & Scheller, J. (2014). Interleukin-6, but not the interleukin-6 receptor plays a role in recovery from dextran sodium sulfate-induced colitis. International Journal of Molecular Medicine, 34, 651-660. https://doi.org/10.3892/ijmm.2014.1825
MLA
Sommer, J., Engelowski, E., Baran, P., Garbers, C., Floss, D. M., Scheller, J."Interleukin-6, but not the interleukin-6 receptor plays a role in recovery from dextran sodium sulfate-induced colitis". International Journal of Molecular Medicine 34.3 (2014): 651-660.
Chicago
Sommer, J., Engelowski, E., Baran, P., Garbers, C., Floss, D. M., Scheller, J."Interleukin-6, but not the interleukin-6 receptor plays a role in recovery from dextran sodium sulfate-induced colitis". International Journal of Molecular Medicine 34, no. 3 (2014): 651-660. https://doi.org/10.3892/ijmm.2014.1825